Antibodies to CD40

Details Antibodies to CD40 Antibodies to CD40

1995-09-08

1998-09-01

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 5303873, 5303881, 5303882, 53038822, 5303887, 53038873, 5303896, 435326, 435328, 435332, 435334, 435343, 4353431, 435346, C07K 1628, C07K 1618, C12N 512

Patent

active

058012273

ABSTRACT:
The present invention provides monoclonal antibodies and binding proteins which specifically bind to CD40 and are capable of blocking binding of CD40 to CD40 ligand.

REFERENCES:
patent: 5247069 (1993-09-01), Ledbetter
patent: 5397703 (1995-03-01), DeBoer et al.
Pen Hartog et al. Immunotechnology 2(4) 299 (1996).
Barrett et al., "CD40 Signaling Activates CD11a/CD18 (LFA-1)-Mediated Adhesion in B Cells," J. Immunol. 146:1722, Mar. 1991.
Gordon et al., "Resting B Lymphocytes Can Be Triggered Directly Through The CDw40 (Bp50) Antigen," J. Immunol. 140:1425, Mar. 988.
Valle et al., "Activation of human B lymphocytes through CD-40 and interleukin 4," Eur. J. Immunol. 19:1463, 1989.
Clark and Ledbetter, "Activation of B human cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50," Proc. Natl. Acad. Sci. USA 83:4494, Jun. 1986.
Gordon et al, "Two surface antigens, CD23 (p45) and a novel p50 molecule, deliver distinct progression signals to activated B-lymphocytes," A.J. McMichael ed., Oxford University Press, Oxford, p. 426.
Paulie et al., "The Human B Lymphocyte and Carcinoma Antigen, CDw40, Is A Phosphoprotein Involved In Growth Signal Transduction," J. Immunol. 142:590, Jan. 1989.
Gordon et al., "Synergistic interaction between interleukin 4 and anti-Bp50 (Cdw40) revealed in a novel B cell restimulation assay," Eur. J. Immunol. 17:1535, 1987.
Jabara et al., "CD40 and IgE: Synergism between Anti-CD40 Monoclonal Antibody and Interleukin 4 in the Induction of IgE Synthesis by Highly Purified Human B Cells," J. Exp. Med. 172:1861, Dec. 1990.
Gascan et al., "Anti-CD40 Monoclonal Antibodies Or CD.sup.+ Cell Clones and IL-4 Induce IgG4 And IgE Switching In Purified Human B Cells Via Different Signaling Pathways," J. Immunol. 147:8, Jul. 1991.
Gordon and Guy, "The molecules controlling B lymphocytes," Immunol. Today 8:339, 1987.
Cairns et al., "Soluble CD23 is released by B lymphocytes cycling in response to interleukin 4 and anti-Bp50 (CDw40)" Eur. J. Immunol. 18:349, 1988.
Clark and Shu, "Association Between IL-6 and CD40 Signaling IL-6 Induces Phosphorylation of CD40 Receptors," J. Immunol. 145:1400, Sep. 1990.
Banchereau et al., "Long Term Human B Cell Lines Dependent on Interleukin-4 and Antibody to CD40," Science 241:70, Jan. 1991.
Liu et al, "Mechanism of antigen-driven selection in germinal centres," Nature 342:929, Dec. 1989.
Howard et al., Abstract "Antibodies to Murine CD40 Stimulate Normal B Cells But Inhibit Proliferation of B Lymphoma Cells," from Keystone Meetings, Jan./Feb. 1993.
Fanslow et al, Soluble Forms of CD40 Inhibit Biologic Responses of Human B Cells, J. Immunol. 149:655, Jul. 1992.
Rousset et al., "Cytokine-induced Proliferation and Immunoglobulin Production of Human B Lymphocytes Triggered through Their CD40 Antigen," J. Exp. Med. 173:705, Mar. 1991.
Splawski et al., "Immunoregulatory Role of CD40 in Human B Cell Differentiation," J. Immunol. 150:1276, Feb. 1993.
Dorken et al. Leucocyte Typing IV Knapp et al. 90-91 (1992).
Harris et al. TIBTECH 11:42-44 (1993).
I. Kwekkeboom et al. Immunology 79:439-444 (1993).

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