Antibodies to CD23, derivatives thereof, and their...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C530S387300, C530S388100, C530S388220

Reexamination Certificate

active

07008623

ABSTRACT:
The invention relates to antibodies which bind to the CD23 (FCεRII) type II molecule particularly altered antibodies including antibodies which bind to the CD23 (FCεRII) type II molecule characterized by an affinity constant equal to or greater than 1×109Ka Mol−1, the preparation of such antibodies, pharmaceutical compositions which contain such antibodies and their use in therapy particularly in the treatment of autoimmune and inflammatory disorders.

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C. Plater-Zyberk et al.: “Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo.” Nature Medicine, vol. 1, No. 8, (Aug. 1995) pp. 781-785, New York, NY, USA.
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