Antibodies to bufalin prevent inhibition of Na/K ATPase and...

Details Antibodies to bufalin prevent inhibition of Na/K ATPase and... Antibodies to bufalin prevent inhibition of Na/K ATPase and...

2009-01-14

2011-11-22

Wen, Sharon (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S141100, C424S130100

Reexamination Certificate

active

08062639

ABSTRACT:
The present invention relates to compositions and methods of use thereof for treatment of clinical conditions manifested from and/or exacerbated by a decrease or an inhibition of Na/K ATPase activity. The invention relates to composition comprises monoclonal or polyclonal antibodies to bufalin and/or bufalin sulfate, or vaccination against bufalin and/or bufalin sulfate, which prevents or attenuates inhibition of Na/K ATPase activity thereby attenuating the adverse physiological effects of bufalin and/or bufalin sulfate inhibition. The invention also relates to methods of treating hemorrhagic, septic shock, cardiogenic shock, shock resulting from physical trauma, diabetes, mental depression, bipolar disorder and schizophrenia comprising administering a therapeutically effective amount of an bufalin monoclonal or polyclonal antibody.

REFERENCES:
patent: 2006/0134106 (2006-06-01), Adair

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