Antibodies to .beta.-amyloids or their derivatives and use there

Details Antibodies to .beta.-amyloids or their derivatives and use there Antibodies to .beta.-amyloids or their derivatives and use there

1997-12-08

1999-09-21

Duffy, Patricia A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435331, 5303879, 5303881, C12D 2104, C07K 1600

Patent

active

059553170

ABSTRACT:
According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.

REFERENCES:
patent: 5750349 (1998-05-01), Suzuki et al.
Supplemental European Search Report, mailed Jan. 26, 1998, application No. 94904758.3.
Ghiso, et al., Biochem J. (1992) 288, 1053-1059.
Seubert, et al., Nature, vol. 359, pp. 332-325 (1992).
Seubert, et al., Nature, 359:325-327 (1992).
Morris, et al., Neurology, 39:1159-1165 (1989).

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