Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Patent
1997-06-19
1999-11-16
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
4241411, 4241511, 4241661, 5303879, 5303884, 5303895, 536 237, A61K 39395, A61K 3940, C07K 1600, C07H 2104
Patent
active
059852771
ABSTRACT:
The present invention relates to antibodies to a purified stress protein of 86 Kd and fragments thereof isolated from the genus Corynebacterium. Particular fragments include those with apparent molecular weights of 50 Kd and 52 Kd. The stress protein has been found to be an immunodominant conserved antigen. Patients with Corynebacterium jeikeium septicemia or endocarditis have antibody to the 52 Kd breakdown product. The protein cross-reacts with a peptide antigen KVIRKNIVKKMIE using a mouse monoclonal antibody against the peptide. The antibodies are useful for diagnosis and treatement of Corynebacterium infections and diseases.
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Caputa Anthony C.
Navarro Mark
The Victoria University of Manchester
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