Antibodies to antiangiogenic compositions and methods

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S324000, C530S387700, C530S387900, C530S388100, C435S810000, C435S325000, C435S326000, C435S331000, C435S344100, C435S330000

Reexamination Certificate

active

07101979

ABSTRACT:
Antibody to endostatin protein that is an inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 18 kDa as determined by non-reduced gel electrophoresis, and approximately 20 kDa as determined by reduced gel electrophoresis and corresponds to a C-terminal fragment of collagen type XVIII, and methods of detecting and treating angiogenesis-related disease therewith.

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