Antibodies to angiogenin: immunotherapeutic agents

Details Antibodies to angiogenin: immunotherapeutic agents Antibodies to angiogenin: immunotherapeutic agents

1995-01-24

1996-05-28

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds hormone or other secreted growth regulatory factor,...

4241301, 4241391, 4241451, 435 723, 436 64, 5303871, 5303881, 5303882, 53038823, 53038824, 5303892, A61K 39395

Patent

active

055209149

ABSTRACT:
This invention relates to the production of antibodies to angiogenin or to fragments thereof and to methods of inhibiting angiogenesis in mammals by administering to mammals such antibodies or Fab or F(ab').sub.2 fragments thereof so as to inhibit angiogenic activity. In addition, this invention relates to pharmaceutical compositions comprising therapeutically effective amounts of antibody that are immunologically reactive with angiogenin and which can be administered to inhibit angiogenesis.

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Brown et al., 1980, The Lancet 1: 682-685.
Svet-Moldavskii, 1977, Vopr. onkol. (Leningrad) 23: 74-76 (in Russian with English translation attached).
Folkman, 1974, Cancer Res. 34: 2109-2113.

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