Antibodies to angiogenin: immunotherapeutic agents

Details Antibodies to angiogenin: immunotherapeutic agents Antibodies to angiogenin: immunotherapeutic agents

1987-08-06

1989-08-01

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 530395, 530808, 530809, 530828, 530399, 43524027, 935104, A61K 39395, C07K 1516

Patent

active

048532193

ABSTRACT:
This invention relates to the production of antibodies to angiogenin or to fragments thereof and to methods of inhibiting angiogenesis in mammals by administering to mammals such antibodies or Fab fragments thereof so as to inhibit angiogenic activity. In addition, this invention relates to pharmaceutical compositions comprising therapeutically effective amounts of antibody that are immunologically reactive with angiogenin and which can be administered to inhibit angiogenesis.

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patent: 4727137 (1988-02-01), Vallee et al.
Lancet 1, 682, Mar. 1980, Brown et al.
Fett et al., Biochemistry, vol. 24, pp. 5480-5486 (1985).
Shapiro et al., Biochemistry, 26(16), 5141-5146, 1987 (mid-August).
Osthoff et al., Bioch. Biophys. Res. Comm., 146(3), (Aug. 1987) pp. 945-952.

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