Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-05-02
1997-07-29
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4241431, 4241411, 435334, 435332, 5303881, A61K 39395, G01N 3353, C12N 500, C07K 1600
Patent
active
056521103
ABSTRACT:
The invention relates to monoclonal antibodies to the .alpha.v.beta.3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on .alpha.v.beta.3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.
REFERENCES:
patent: 4707352 (1987-11-01), Stavrianpoulos
patent: 5057604 (1991-10-01), Brown
Roitt (1991) "Essential Immunology", Blackwell Scientific Publications, Oxford, pp. 65-68 & 74.
Davies et al (1989) J. Cell Biol. 109 : 1817-1826.
Charo et al., "The Vitonectin Receptor .alpha..sub.3 .beta..sub.3 Binds Fibronectin and Acts in Concert with .alpha..sub.5 .beta..sub.1 in Promoting Cellular Attachment and Spreading in Fibronectin" The Journal of Cell Biolo Part 1):2795-2800 (Dec. 1990).
Cheresh et al., "Biosynthetic and Functional Properties of an Arg-Gly-Asp-directed Receptor Involved in Human Melanoma Cell Attachment to Vitronectin, Fibrinogen, and von Willebrand Factor" Journal of Biological Chemistry 262(36):17703-17711 (Dec. 1987).
Davies et al., "The Osteoclast Functional Antigen, Implicated in the Regulation of Bone Resorption, is Biochemically Related to the Vitronectin Receptor" The Journal of Cell Biology 109:1817-1826 (Oct. 1989).
Goding, "Fragmentation of Monoclonal Antibodies" Monoclonal Antibodies: Principles and Practice, Academic Press, Inc. pp. 118-124 (1983).
Goding, "Solid-phase Radioimmunoassay Soluble Protein Antigen" Monoclonal Antibodies: Principles and Practice, Academic Press, Inc. pp. 75-84 (1983).
Helfrich et al., "Integrins on rat Osteoclasts: Characterization of Two Monoclonal Antibodies (F4 and F11) to Rat .beta..sub.3 " Journal of Bone and Mineral Research 7(3):345-351 (1992).
Horton, "Osteoclast-Specific Antigens" ISI Atlas of Science: Immunology pp. 35-43 (1988).
Horton et al., "Arg-Gly-Asp (RGD) Peptides and the Anti-Vitronectin Receptor Antibody 23C6 Inhibit Dentine Resorption and Cell Spreading by Osteoclasts" Experimental Cell Research 195:368-375 (1991).
Horton et al., "Monoclonal Antibodies to Osteoclastomas (Giant Cell Bone Tumors): Definition of Osteoclast-specific Cellular Antigens" Cancer Research 45:5663-5669 (Nov. 1985).
Horton et al., "Perspectives: Adhesion Receptors in Bone" Journal of Bone and Mineral Research 4(6):803-808 (1989).
Horton, M., "Current Status Review Vitronectin receptor: tissue specific expression or adaptation to culture?" Int. J. Exp. Pathol. 71:741-759 (1990).
Hynes, R., "Integrins: A Family of Cell Surface Receptors" Cell 48:549-554 (Feb. 1987).
Nesbitt et al., "Epitope analysis of teh Vitronectin receptor (CD51)" Leukocyte Typing IV: White Cell Differentiation Antigens, Knapp et al. p. 1037 (1991).
Nesbitt et al., "Epitope Analysis of the Vitronectin Recptor .alpha. and .beta. Chains" Tissue Antigens (abstract only), Knapp, W. vol. 33:357 (1989).
Ruoslahti et al., "Arg-Gly-Asp: A Versatile Cell Recognition Signal" Cell 44:517-518 (Feb. 1986).
Ruoslahti et al., "New Perspectives in Cell Adhesion: RGD and Integrins" Science 238:491-497 (Oct. 1987).
Waldmann, T., "Monoclonal antibodies in diagnosis and therapy" Science 252:1657-1662 (Jun. 1991).
Bodary Sarah C.
Chuntharapai Anan
Horton Michael A.
Kim Kyung Jin
Dreger Walter H.
Ebert Ray F.
Feisee Lila
Genentech Inc.
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