Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-05-23
2006-05-23
Nolan, Patrick J. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S389100, C435S007100, C435S007400
Reexamination Certificate
active
07049412
ABSTRACT:
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
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M.A. PRATTA, M.D. TORTORELLA, AND E C ARNER “Age-related Changes in Aggrecan Glycosylation Affect Cleavage by Aggrecanase”J. Biol. Chem. 275 (50): 39096-39102. Dec. 15, 2000.
Arner Elizabeth C.
Burn Timothy C.
Copeland Robert A.
Decicco Carl P.
Liu Ruiqin
Bristol-Myers Squibb Pharma Comp.
Lange Keith R.
Nolan Patrick J.
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