Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-07-22
1993-07-27
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 721, 43524027, 5303881, 436501, 436506, G01N 3353, G01N 33564, G01N 33577, C12N 520
Patent
active
052310000
ABSTRACT:
Monoclonal antibodies to a 28-mer peptide present within A4-amyloid are described. These antibodies exhibit unexpected specificity for amyloid plaque structures previously unrecognized in Alzheimer's disease brains. These monoclonal antibodies are useful as reagents for use in assays and imaging of A4-amyloid in Alzheimer's disease patients.
REFERENCES:
patent: 4376110 (1983-03-01), David et al.
patent: 4666829 (1987-05-01), Glenner
Pardridge, W. M. et al May 1987 Biochem Biophys Res. Comm 145(1):241-8 "High Molecular . . . ".
Wong, C. W. et al. Dec. 1985, P.N.A.S. 82; 8729-8732, "Neuritic plaques . . . ".
Kang, J. et al. Feb. 1987 Nature 325:733-736 "The Precursor of Alzheimer's Diseases Amyloid . . . ".
Kohler, G and C. Milstein, Nature (256:495-8), Aug. 1975, "Continuous cultures . . . ".
White et al., Principles of Biochemistry, Fourth Edition, McGraw-Hill, pp. 92-93 (1968).
Salim et al., Familial Alzheimer's Disease: Molecular Genetics, Clinical Prospects and Societal Issues, Marcel Dekker, N.Y., pp. 153-165 (1989).
Sajdel-Sulkowska et al., JAGS 36:558-564 (1988).
Majocha et al., Proc. Natl. Acad. Sci., U.S.A., 85:6182-6186 (1988).
Benes, F. M. et al., Soc. Neurosci. 13:abs. 316.15, p. 1153 (1987).
Glenner, G. G., et al., Biochem. Biophys. Res. Comm. 120:885-890 (1984).
Glenner, G. G., et al., Biochem. Biophys. Res. Comm. 122:1131-1135 (1984).
Masters, C. L., et al., Proc. Natl. Acad. Sci. USA 82:4245-4249 (1985).
Masters, C. L., et al., EMBO. J. 4:2757-2763 (1985).
A copy of International Search Report of the International Patent Application No. PCT/US88/03590.
Pardridge et al., Biochem. Biophys. Res. Comm. 145:241-248 (1987).
Robakis et al., Chemical Abstr. 107: Abstr. No. 71938a (1987).
Majocha Ron
Marotta Charles A.
Zain Sayeeda
Cunningham T.
Nucker Christine M.
The McLean Hospital
University of Rochester
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