Antibodies to A4 amyloid peptide

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 72, 435 721, 43524027, 5303881, 436501, 436506, G01N 3353, G01N 33564, G01N 33577, C12N 520

Patent

active

052310000

ABSTRACT:
Monoclonal antibodies to a 28-mer peptide present within A4-amyloid are described. These antibodies exhibit unexpected specificity for amyloid plaque structures previously unrecognized in Alzheimer's disease brains. These monoclonal antibodies are useful as reagents for use in assays and imaging of A4-amyloid in Alzheimer's disease patients.

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