Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-08-07
2010-06-29
Swope, Sheridan (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388260, C530S300000
Reexamination Certificate
active
07745588
ABSTRACT:
The invention relates to a low molecular weight peptide (or suite of related peptides) isolated from the submaxillary saliva glands of shrews of the speciesBlarinaas a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic or as an insecticide.
REFERENCES:
patent: 5424286 (1995-06-01), Eng
patent: 6326020 (2001-12-01), Kohane et al.
patent: 7119168 (2006-10-01), Stewart et al.
patent: 7273850 (2007-09-01), Stewart et al.
patent: 2006/0217302 (2006-09-01), Stewart et al.
patent: 10236963 (1998-08-01), None
GenCore version 5.1.7, pp. 3-4 (Result 5), Feb. 1, 1996 (created, last sequence update), Oct. 25, 2004 (last annotation update).
Cai, Z. et al., “Solution Structure of BmBKTx1, a New BKCA1Channel Blocker from the Chinese Scorpion Buthus martensi Karsch”, Biochemistry, vol. 43, No. 13, pp. 3764-3771, 2004.
Christenbury, P., “A Study of the Ecology ofBlarina brevicaudiain North Carolina and of the Effect of Shrew Toxin on the Liver and Kidneys of Mice”. A thesis submitted to the Graduate Faculty of Wake Forest College in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Biology, Aug. 1966.
Dekker, E. et al. “The epithelial calcium channels, TRPV5 and TRPV6: from identification towards regulation”, Cell Calcium, vol. 33, pp. 497-507, 2003.
Dufton, M., “Venomous Mammals”, Pharmac. Ther., vol. 53, pp. 199-215, 1992.
Ellis, S. et al., “Properties of a Toxin From the Salivary Gland of the Shrew,Blarina brevicauda”, The Journal of Pharmacology & Experimental Therapeutics, vol. 114, No. 2, pp. 127-137, 1955.
GenCore version 5.1.7, pp. 3-4 (Result 5), UniProt ALP47969 Feb. 1, 1996.
George, S. et al., “Blarina brevicauda”, Mammalian Species, No. 261, pp. 1-9, 3 Figures, 1986.
Kita, M. et al., “Blarina toxin, a mammalian lethal venom from the short-tailed shrewBlarina brevicauda: Isolation and characterization”, Proceedings of the National Academy of Sciences of the United States of America, vol. 101, No. 20, pp. 7542-7547, 2004.
Lecchi, P. et al., “The Structure of Synenkephalin (Pro-Enkephalin1-73) Is Dictated by Three Disulfide Bridges”, Biochemical and Biophysical Research Communications, vol. 232, pp. 800-805, 1997.
Martin, I., “Venom of the Short-Tailed Shrew (Blarina brevicauda) As an Insect Immobilizing Agent”, Journal of Mammalogy, vol. 62, No. 1, pp. 189-192, 1978.
Montell, C., “The venerable inveterate invertebrate TRP channels”, Cell Calcium, vol. 33, pp. 409-417, 2003.
Mount Allison University, “Potent Peptide Paralytic Agent”, Version 1, Jun. 2003.
Mount Allison University, “Potent Peptide Paralytic Agent”, Version 2, Jul. 2003.
Pearson, O., “On the cause and nature of poisonous action produced by the bite of a shrew (Blarina brevicauda,” Journal of Mammalogy, pp. 159-166, (1942).
Peng, J. et al., “CaT1 Expression Correlates with Tumor Grade in Prostate Cancer”, Biochemical and Biophysical Research Communications, vol. 282, pp. 729-734, 2001.
Peng, J. et al., “Human Calcium Transport Protein CaT1”, Biochemical and Biophysical Research Communications, vol. 278, pp. 326-332, 2000.
Pohl, M. et. al., “Molecular Cloning of the Helodermin and Exendin-4 cDNAs in the Lizard”, The Journal of Biological Chemistry, vol. 273, No. 16, pp. 9778-9784, 1998.
Pucek, M., Chemistry and Pharmacology of Insertivore Venoms, Chapter 3 of Venomous Animals and Their Venoms edited by W. Bucherl, Academic Press, New York—London, pp. 43-50, 1968.
Smart, P., “Shrew Saliva Spells Relief? Prof. Jack Stewart makes breakthrough medical discovery”, the argosy, Jan. 16, 2003.
“The venom of the shrew maybe the new Botox”, National Post, Science Section, Biochemistry, Dec. 20, 2002.
Tomasi, T., “Function of Venom in the Short-Tailed ShrewBlarina brevicauda”, Journal of Mammalogy, vol. 59, No. 4, pp. 852-854, 1978.
Zhuang, L. et al., “Calcium-Selective Ion Channel, CaT1, Is Apically Localized in Gastrointestinal Tract Epithelia and Is Aberrantly Expressed in Human Malignancies”, Laboratory Investigation, vol. 82, No. 12, pp. 1755-1764, 2002.
Steeves Bradley J.
Stewart John M.
Vernes Karl
Ballard Spahr LLP
BioProspecting NB Inc.
Swope Sheridan
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