Antibodies to a cathepsin C homolog

Details Antibodies to a cathepsin C homolog Antibodies to a cathepsin C homolog

2007-03-27

2007-03-27

Gambel, Phillip (Department: 1644)

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

C436S548000, C424S130100, C424S139100, C424S146100, C435S070210, C435S449000, C435S212000, C435S338000, C435S183000, C435S195000, C435S326000, C530S387100, C530S387300, C530S387900, C530S388100, C530S388200, C530S388260, C530S389100

Reexamination Certificate

active

09520941

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.

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