Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-05-17
2011-05-17
Sang, Hong (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
Reexamination Certificate
active
07943741
ABSTRACT:
The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.
REFERENCES:
patent: 4897348 (1990-01-01), Johnson et al.
patent: 5011912 (1991-04-01), Hopp et al.
patent: 5278287 (1994-01-01), Rollins et al.
patent: 5306709 (1994-04-01), Gewirtz
patent: 5346686 (1994-09-01), Lyle et al.
patent: 5413778 (1995-05-01), Kunkel et al.
patent: 5474983 (1995-12-01), Kuna et al.
patent: 5602008 (1997-02-01), Wilde et al.
patent: 5936068 (1999-08-01), Wilde et al.
patent: 6001649 (1999-12-01), Caput et al.
patent: 6096300 (2000-08-01), Hromas
patent: 6174995 (2001-01-01), Li et al.
patent: 6673344 (2004-01-01), Li et al.
patent: 0488 900 (1991-11-01), None
patent: 0538 030 2 (1993-04-01), None
patent: 07089866 (1995-04-01), None
patent: WO-90/06321 (1990-06-01), None
patent: WO-91/04274 (1991-04-01), None
patent: PCT/GB90/02017 (1991-07-01), None
patent: WO-91/12815 (1991-09-01), None
patent: WO-92/05198 (1992-04-01), None
patent: WO-92/20372 (1992-11-01), None
patent: WO-95/17092 (1995-06-01), None
patent: WO-95/31467 (1995-11-01), None
patent: WO-95/31468 (1995-11-01), None
patent: WO-96/05856 (1996-02-01), None
patent: WO-96/06169 (1996-02-01), None
patent: WO-96/09062 (1996-03-01), None
patent: WO-96/16979 (1996-06-01), None
patent: WO-96/39520 (1996-12-01), None
patent: WO-96/39521 (1996-12-01), None
patent: WO-96/39522 (1996-12-01), None
patent: WO-97/15594 (1997-05-01), None
patent: WO-97/15595 (1997-05-01), None
patent: WO-97/31098 (1997-08-01), None
patent: WO 97/35982 (1997-10-01), None
patent: WO-98/01557 (1998-01-01), None
patent: WO-98/09171 (1998-03-01), None
patent: WO-98/11226 (1998-03-01), None
patent: WO-98/14573 (1998-04-01), None
patent: WO-98/17800 (1998-04-01), None
patent: WO-98/21330 (1998-05-01), None
patent: WO-99/47674 (1999-09-01), None
patent: WO-00/46248 (2000-08-01), None
GenBank Accession No. AA297433 (Apr. 18, 1997).
GenBank Accession No. AA403048 (May 16, 1997).
GenBank Accession No. AA404346 (May 16, 1997).
GenBank Accession No. AA426245 (Oct. 16, 1997).
GenBank Accession No. AA739063 (Jan. 14, 1998).
GenBank Accession No. AAB38703 (Dec. 16, 1996).
GenBank Accession No. AAB61534.1 (Aug. 6, 1996).
GenBank Accession No. AAC50943.1 (Aug. 6, 1996).
GenBank Accession No. AC002482 (Aug. 21, 1997).
GenBank Accession No. AI735669 (Jun. 14, 1999).
GenBank Accession No. AI925360 (Sep. 2, 1999).
GenBank Accession No. AJ000979 (Jun. 30, 1997).
GenBank Accession No. AJ001634 (Sep. 10, 1997).
Genbank Accession No. AAW56690 (Jun. 3, 1997).
GenBank Accession No. CAA04888 (Sep. 10, 1996).
GenBank Accession No. CAA66950 (Dec. 16, 1997).
GenBank Accession No. CAB01111 (Jul. 30, 1996).
GenBank Accession No. CAB01112 (Jul. 30, 1996).
GenBank Accession No. D17181 (Jun. 21, 1993).
GenBank Accession No. D31065 (Feb. 8, 1995).
GenBank Accession No. D86955 (Mar. 6, 1997).
GenBank Accession No. I35613 (Feb. 22, 1997).
GenBank Accession No. AAR29479 (Apr. 25, 1995).
GenBank Accession No. T27336 (Dec. 6, 1994).
GenBank Accession No. T27433 (Dec. 6, 1994).
GenBank Accession No. T64134 (Feb. 17, 1995).
GenBank Accession No. T64262 (Feb. 17, 1995).
GenBank Accession No. U46767 (Dec. 14, 1996).
GenBank Accession No. U64197 (Jun. 25, 1997).
GenBank Accession No. U77035 (Jan. 23, 1997).
GenBank Accession No. W44398 (Jun. 11, 1998).
GenBank Accession No. AAW57475 (Sep. 7, 1998).
GenBank Accession No. W61279 (Sep. 24, 1998).
GenBank Accession No. X98306 (Jul. 20, 1998).
GenBank Accession No. Z77650 (Jul. 30, 1996).
GenBank Accession No. Z77651 (Jul. 30, 1996).
Geneseq Accession No. AAR95690 (Dec. 20, 1996).
Geneseq Accession No. AAW17660 (Dec. 16, 1997).
Geneseq Accession No. AAT90880 (May 21, 1998).
Geneseq Accession No. AAT90883 (May 21, 1998).
Geneseq Accession No. AAV28591 (Aug. 17, 1998).
Geneseq Accession No. AAW30191 (May 21, 1998).
Geneseq Accession No. AAW44398 (Jun. 11, 1998).
Geneseq Accession No. AAW56087 (Aug. 17, 1998).
Genseq Accession No. AAR93087 (Aug. 27, 1996).
Genseq Accession No. AAW22670 (Mar. 19, 1998).
Genseq Accession No. AAR29479 (Apr. 22, 1993).
Abiko, et al.., “Expression of MIP-3alpha/CCL20, a macrophage inflammatory protein in oral squamous cell carcinoma,”Arch. Oral Biol., 48(2):171-175 (Feb. 2003).
Adema et al., “A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells,”Nature, 387:713-717 (Jun. 1997).
Akahoshi, et al., “Production of macrophage inflammatory protein 3 (MIP-3) (CCL20) and MIP-3 (CCL19) by human peripheral blood neutrophils in response to microbial pathogens,”Infect. Immun., 71(1):524-526 (Jan. 2003).
Ambrosini, et al., “Astrocytes are the major intracerebral source of macrophage inflammatory protein-3slaph/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro,”Glia, 41(3):290-300 (Feb. 2003).
Bennouna, et al., “Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection,”J. Immunol., 171:6052-6058 (Dec. 2003).
Berger, M.S., “Isolation of Monocyte Chemotactic Protein-4,”Clinical Res., 42(2):305A (1994).
Bischoff et al., “Monocyte Chemotactic Protein 1 Is a Potent Activator of Human Basophils,”J. Exp. Med., 175:1271-1275 (May 1992).
Blum et al., “Three Human Homologs of a Murine Gene Encoding an Inhibitor of Stem Cell Proliferation,”DNA and Cell Biol., 9(8)589-602 (1990).
Brown et al., “A Family of Small Inducible Proteins Secreted by Leukocytes are Members of a New Superfamily that Includes Leukocyte and Fibroblast-Derived Inflammatory Agents, Growth Factors, and Indicators of Various Activation Processes,”J. Immunol., 142(2):679-687 (Jan. 15, 1989).
Clements et al., “Biological and Structural Properties of MIP-1a Expressed in Yeast,”Cytokine, 4(1):76-82 (Jan. 1992).
Craddock et al., “Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice,”Blood, 90(12):4779-4788 (Dec. 15, 1997).
Crittenden, et al., “Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity,”Cancer Res., 63:5505-5512 (Sep. 1, 2003).
Derynck et al., “Recombinant Expression, Biochemical Characterization, and Biological Activities of the Human MGSA/gro Protein,”Biochem., 29(44):10225-10233 (1990).
Dieu-Nosjean, et al., “Macrophage inflammatory protein 3 is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting langerhans cell precursors,”J. Exp. Med., 192(5):705-717 (Sep. 2000).
Furuta et al., “Production and Characterization of Recombinant Human Neutrophil Chemotactic Factor,”J. Biochem., 106:436-441 (1989).
Fushimi, et al., “Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tu
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Sang Hong
LandOfFree
Antibodies that specifically bind to chemokine β-4 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies that specifically bind to chemokine β-4, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies that specifically bind to chemokine β-4 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2659983