Antibodies that specifically bind to and inhibit human synovial

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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53038826, 5303891, 43524027, C07K 1618, C12N 520

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active

055525300

ABSTRACT:
Antibodies that specifically bind to and inhibit the enzymatic activity of synovial phospholipase A.sub.2 Type A are described. The antibodies may be used in assays for detection of synovial phospholipase A.sub.2 in biological samples.

REFERENCES:
O'Hara et al., "Dog and rat pancreatic phospholipases A.sub.2 : Complete amino acid sequences deduced from complementary DNAs" J. Biochem. (1986) 99:733-739.
Dufton et al., "Conformational properties of phospholipases A.sub.2 : Secondary-structure prediction, circular dichroism and relative interface hydrophobicity" Eur. J. Biochem. (1983) 137:537-544.
Grataroli et al., "Studies on prophospholipase A.sub.2 and its enzyme from human pancreatic juice: Catalytic properties and sequence of the N-terminal region" Eur. J. Biochem. (1992) 122:111-117.
Renetseder et al., "A comparison of the crystal structures of phospholipase A.sub.2 from bovine pancreas and Crotalus atrox venom" J. Biol. Chem. (1985) 260:11627-11634.
Pruzanski et al., "Inflammatory effect of intradermal administration of soluble phospholipase A.sub.2 in rabbits" J. Invest. Dermatol. (1986) 86:380-383.
Verger et al., "Novel intestinal phospholipase A.sub.2 : Purification and some molecular characteristics" Biochemistry (1982) 21:6883-6889.
Gray et al., "The purification and characterization of a phospholipase A.sub.2 activity from the 106 000 X g pellet (microsomal fraction) of bovine brain acting on phosphatidylinositol" Can. J. Biochim. (1982) 60:108-117.
DeWinter et al., "Purification of rat liver mitochondrial phospholipase A.sub.2 " Biochim. Biophys. Acta (1982) 712:332-341.
Franson et al., "Isolation and characterization of a membrane-associated, calcium-dependent phospholipase A.sub.2 from rabbit lung"Lung (1982) 160:275-284.
Garcia et al., "Lung surfactant synthesis: A Ca.sup.++ -dependent microsomal phospholipase A.sub.2 in the lung" Biochim. Biophys. Res. Comm. (1975) 64:128-135.
Sahu et al., "Characterization of phospholipase A from pulmonary secretions of patients with alveolar proteinosis" Biochim. Biophys. Acta (1977) 489:307-317.
Teramoto et al., "Purification and some properties of rat spleen phospholipase A.sub.2 " J. Biochim. (1983) 93:1353-1360.
Trotter et al., "The role of phospholipases from inflammatory macrophages in demyelination" Neurochem. Res. (1986) 11:349-361.
Lanni et al., "Localization and partial purification of a neutral-active phospholipase A.sub.2 from BCG-induced rabbit alveolar macrophages" Biochim. Biophys. Acta (1981) 658:54-63.
Vadas et al., "The release of phospholipase A.sub.2 from aggregated platelets and stimulated macrophages of sheep" Life Sciences (1980) 26:1721-1729.
Vadas et al., "Extracellular phospholipase A.sub.2 mediates inflammatory hyperaemia" Nature (1981) 293:583-585.
Wightman et al., "The selective release of phospholipase A.sub.2 by resident mouse peritoneal macrophages" Biochim. J. (1981) 200:441-444.
Franson et al., "Some properties of phospholipases of alveolar macrophages" Biochim. Biophys. Acta (1973) 296:365-373.
Traynor et al., "Phospholipase A.sub.2 activity of lysosomal origin secreted by polymorphonuclear leucocytes during phagocytosis or on treatment with calcium" Biochim. Biophys. Acta (1981) 665:571-577.
Franson et al., "Phospholipase A activity associated with the membranes of human polymorphonuclear leucocytes" Biochim. J. (1977) 167:839-841.
Kramer et al., "Isolation of phospholipase A.sub.2 from sheep erythrocyte membranes in the presence of detergents" Biochim. Biophys. Acta (1978) 507:381-394.
Forst et al., "Structural and functional properties of a phospholipase A.sub.2 purified from an inflammatory exudate" Biochemistry (1986) 25:8381-8385.
Chang et al., "Interleukin 1 activates phospholipase A.sub.2 in rabbit chondrytes: A possible signal for IL 1 action" J. Immunol. (1986) 136:1283-1287.
Hayakawa et al., "Purification and characterization of membrane-bound phospholipase A.sub.2 from rat platelets" J. Biochem. (1988) 103:263-266.
Hayakawa et al., "Amino acid composition and NH.sub.2 -terminal amino acid sequence of rat platelet secretory phospholipase A.sub.2 " J. Biochim. (1987) 101:1311-1314.
Jesse et al., "Modulation of purified phospholipase A.sub.2 activity from human platelets by calcium and indomethacin" Biochim. Biophys. Acta (1979) 575:467-470.
Apitz-Castro et al., "Isolation of homogeneous phopholipase A.sub.2 from human platelets" Biochim. Biophys. Res. Comm. (1979) 91:63-71.
Van Den Bosch, "Intracellular phospholipases A" Biochim. Biophys. Acta (1980) 604:191-246.
Stefanski et al., "Purification of a soluble phospholipase A.sub.2 from synovial fluid in rheumatoid arthritis" J. Biochim. (1986) 100:1297-1303.
Vadas et al., "Characterization of extracellular phospholipase A.sub.2 in rheumatoid synovial fluid" Life Sciences (1985) 36:579-587.
Vadas et al., "Role of extracellular phospholipase A.sub.2 in inflammation" Adv. Inflammation Res. (1984) 7:51-59.
Pruzanski et al. "Phospholipase A.sub.2 activity in sera and synovial fluids in rheumatoid arthritis and osteoarthritis. Its possible role as a proinflammatory enzyme" J. Rheumatol. (1985) 12:211-216.
Silverman et al., "Correlation of phospholipase A.sub.2 level and disease activity in juvenile rheumatoid arthritis (JRA)" American Rheumatism Ass'n: 51st Annual Scientific Meeting 9-13 Jun. 1987, Washington D.C., Abstract No. E87.
Dutilh et al., "Improvement of product attributes of mayonnaise by enzymic hydrolysis of egg yolk with phospholipase A.sub.2 " J. Sci. Food Agric. (1981) 32:451-458.
Mazeaud et al., "Free fatty acids and the onset of rancidity in rainbow trout (salmo gairdneri) flesh. Effect of phospholipase A" J. Fish Res. Board Can. (1976) 33:1297-1302.
Okamoto et al., Biochem Biophys. Res Comm. 128:788-794, 1985.
Sevier et al., Clin chem. 27/11:1797-1806, 1981.

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