Antibodies that selectively bind quadruplex nucleic acids

Chemistry: analytical and immunological testing – Biospecific ligand binding assay

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436508, 436518, 436527, 436524, 436529, 436532, 436533, 436536, 436538, 436548, 53038821, G01N 33566, G01N 33551, G01N 33552, G01N 33536

Patent

active

060016574

ABSTRACT:
Antibodies that selectively bind to quadruplex nucleic acids are described. Isolated cells that produce such antibodies, and methods utilizing these antibodies, are also described.

REFERENCES:
patent: 4732847 (1988-03-01), Stuart et al.
Andrzejewski, et al. "Hybridoma Autoantibodies to DNA", The Journal of Immunology, vol. 24, No. 3 (Mar. 1980), pp. 1499-1502.
Lafer, et al., "Antibodies specific for left-handed Z-DNA", Proc. Natl. Acad. Sci., USA, vol. 78, No. 6 (Jun. 1981), pp. 3546-3550.
Hardin, et al., "Stabilization of Z-RNA by Chemical Bromination and Its Recognition by Anti-Z-DNA Antibodies", Biochemistry, vol. 26, No. 16 (1987), pp. 5191-5199.
Hardin, et al., "Characterization of Anti-Z-RNA Polyclonal Antibodies: Epitope Properties and Recognition of Z-DNA", Biochemistry, vol. 27, No. 11 (1988), pp. 4169-4177.
Huse, et al., "Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda", Science, vol. 246 (Dec. 1989), pp. 1275-1281 and 1250-1251.
Hardin, et al., "Monovalent Cation Induced Structural Transitions in Telomeric DNAs: G-DNA Folding Intermediates", Biochemistry, vol. 30, No. 18 (1991), pp. 4460-4472.
Hardin, et al., "Cation-Dependent Transition between the Quadruplex and Watson-Crick Hairpin Forms of d(CGCG.sub.3 GcG)", Biochemistry, vol. 31, No. 3 (1992), pp. 833-841.
Weisman-Shomer, et al., "QUAD, a Protein from Hepatocyte Chromatin That Binds Selectively to Guanine-rich Quadruplex DNA", The Journal of Biological Chemistry, vol. 268, No. 5 (Feb. 1993), pp. 3306-3312.
Hardin, et al., "Cytosine-Cytosine.sup.+ Base Pairing Stabilizes DNA Quadruplexes and Cytosine Methylation Greatly Enhances the Effect", Biochemistry, vol. 32, No. 22 (1993), pp. 5870-5880.
Macaya, et al., "Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution", Proc. Natl. Acad. Sci. USA, vol. 90 (Apr. 1993), pp. 3745-3749.
Schierer et al., "A Protein from Tetrahymena thermophila That Specifically Binds Parallel-Stranded G4-DNA", Biochemistry, vol. 33, No. 8 (1994), pp. 2240-2246.
Ross et al., "Ion-Induced Stabilization of the G-DNA Quadruplex: Free Energy Perturbation Studies", J. Am. Chem. Soc., vol. 116, No. 14 (1994), pp. 6070-6080.
Weisman-Shomer, et al., "Stabilization Of Tetrahelical DNA By The Quadruplex DNA Binding Protein QUAD", Biochemical and Biophysical Research Communications, vol. 205, No. 1 (Nov. 1994), pp. 305-311.
Huizenga, et al. "A DNA Aptamer That Binds Adenosine and ATP", Biochemistry, vol. 34, No. 2 (1995), pp. 656-665.
Hermann, et al., "Preferential recognition of specific DNA motifs by anti-double-stranded DNA autoantibodies", Eur. J. Immunol., vol. 25 (1995), pp. 1897-1904.

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