Antibodies that react with variant CD44 surface proteins

Details Antibodies that react with variant CD44 surface proteins Antibodies that react with variant CD44 surface proteins

1995-06-07

1999-03-23

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

4241431, 435 723, 435 7021, 435331, 435334, 4353441, 435346, 5303879, 53038885, 5303897, 5303913, A61K 39395, G01N 3358, C12P 2108, C07K 1630

Patent

active

058855750

ABSTRACT:
The inventon relates to antibodies that react with a variant epilope in the extracellular region of a variant CD44 polypeptide, wherein the variant epitope has the amino acid sequence:
I S S T I S T T P R A P D H T K Q N Q D W T Q W N P S H S N P E
V L L Q T T T R M T D V D R N G T T A Y E G N W N P E A H P P L
I H H E H H E E E E T P H S T S T I O A T P S S T T E E T A T Q
K E Q W F G N R W H E G Y R Q T P R E D S H S T T G T A A A S A
H T S H P M Q G R T T P S P E D S S W T D F F N P I S H P M G R
G H Q A G R R (residues 53-219 of SEQ ID NO:4). Methods of using the antibodies to identify variant epitopes also are provided.

REFERENCES:
Seaver, S. Genetic Engineering News, vol. 14, pp. 10, 14, Aug. 14, 1994.
The Dictionary of Immunology, Herber, W. J. et al. (Eds.), Academic Press, New York, NY., 1995.
Volume 1: Immunochemistry, Edited by Weir, D. M. et al., Blackwell Scientific Publications, Boston, MA, Chapter 14 and pp. 38.5-38.6, 1986.
Birnbaum et al., Anticancer Research 8: 1185-1191 (1988).
Matzku et al., Cancer Research 49: 1294-1299 (Mar. 1, 1989).
Lehmann et al., Proc. Natl. Acad. Sci. USA 86: 9891-9895 (1985).
Chan et al., Science 251: 1600-1602 (1991).
Maniatis et al., Molecular Cloning, pp. 382-389 (1982).
Kugelman et al., J. Invest. Dermotol. 99:381-385 (1992).
Bowie et al., Science 247: 1306-1310 (1990).
Kumar et al., Proc. Natl. Acad. Sci. 87: 1337-1341 (1990).
Ellis, Vaccines, Plotkin & Mortiner Eds., W. B. Saunders Co., pp. 568-575 (1988).
Young et al., Proc. Natl. Acad. Sci. 80:1194-1198 (1983).

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