Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1993-12-03
1998-05-19
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241411, 4241431, 4241561, 5303871, 5303881, 53038822, A61K 39395, C07K 1600
Patent
active
057532257
ABSTRACT:
The use and production of immunoglobulins which activate trk receptors and imitate effects of neurotrophins are provided. Immunoglobulins which block trk receptor activation and methods of use are also provided.
REFERENCES:
patent: 5231001 (1993-07-01), Kaplan et al.
patent: 5349055 (1994-09-01), Persson et al.
Drebin JA et al (1985) Cell 41:695-706.
Cordon-Cando et al 1991 Cell 66:173-183.
Ibanez, CF et al. EMBO J 12(6):2281-2293, 1993.
Rovelli G. et al PNAS 90:8717-8721, 1993.
Barker, P.A. et al. "The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins", Molecular and Cellular Biochemistry 110:1 (1992).
Hutton, L.A. et al., "Expression of p75.sup.NGFR TrkA and TrkB, mRNA in Rat C6 Glioma and Type I Astrocyte Cultures", Journal of Neuroscience Research, 32;375 (1992).
Knusel, B. et al., "K-252 Compounds: Modulators of Neurotrophin Signal Transduction", Journal of Neurochemistry, 59:1987 (1992).
Persson, H. et al. "Role and expression of neurotrophins and the trk family of tyrosine kinase receptors in neural growth and rescue after injury", Current Opinion in Neurology and Neurosurgery, 6:11 (1993).
Barde, Y. A., Neuron. 2:1525-1534 (1989).
Collazo, et al., Neuron 9:643-656 (Oct. 1992).
Eager, K., Onc. 6(5):819-824 (May 1991).
Eide, F. E., et al., Exp. Neurol. 121:200-214 (1993).
Greene, L. A. et al., A., Proc. Natl. Acad. Sci. USA 73:2424-2428 (1976).
Hanks, et al. Science 241:42-52 (1988).
Holtzman, et al., Neuron. 9:465-78 (1992).
Hosang, M. et al., J. Biol. Chem. 260:655-662 (1985).
Jing, et al., Neuron. 9:1067-1079 (1992).
Johnson, et al., Cell. 47:545-554 (1986).
Kaplan, et al., Science. 252:554-8 (1991).
Kaplan, et al., Nature 350:158-160 (1991).
Klein, R., et al., Embo. J. 8:3701-3709 (1989).
Klein, et al., Cell. 65:189-197 (1991).
Korsching, S., J. Neurosci. 13:2739-2748 (1993).
Lamballe, et al., Cell 66:967 (1991).
Levi-Montalcini, R., Science 237:1154-1162 (1987).
Loeb, et al., Neuron. 9:1053-1065 (1992).
Martin-Zanca, et al., Mol. Cell. Biol. 9:24-33 (1989).
Martin-Zanca, et al., Genes Dev. 4:683-694 (1990).
Meakin, S. O. et al., Neuron. 6:153-163 (1991).
Middlemas, et al., Mol. Cell. Biol. 11:143-153 (1991).
Obermeier, et al., Embo. J. 12:933-941 (1993).
Ohmichi et al., Biochem. Biophys. Res. Commun. 179:217-223 (1991).
Ohmichi et al., Neuron 9:769-777 (1992).
Pulido et al., EMBO 11:391-404 (1992).
Radeke, et al., Nature 325:593-597 (1987).
Radeke, M. J. et al., Neuron. 7:141-150 (1991).
Schechter, A. L. et al., Cell., 24, 867-874 (1981).
Schechterson, L. C. et al., Neuron. 9:449-463 (1992).
Schneider, R. et al., Oncogene 6:1807-1811 (1991).
Sutter, et al., J. Biol. Chem. 254:5972-5982 (1979).
Vetter, et al., Proc. Natl. Acad. Sci. USA 88:5650-5654 (1991).
Weskamp, G. et al., Neuron. 6:649-663 (1991).
Wheeler, E. F. et al., J. Neurosci. 12:930-945 (1992).
Wyatt, et al., Neuron. 4:421-7 (1990).
Alberts et al., "Molecular Biology of the Cell", published 1989 by Garland Publishing Inc. (N.Y.), pp. 333-334.
Eager, K.B. Oncogene. 6:819-824, 1991.
Steele-Perkins, G. and Roth, R.A. J. Biol. Chem. 265(16):9458-9463, Jun. 1990.
Austin Leeann R.
Clary Douglas O.
Reichardt Louis F.
Weskamp Gisela
Feisee Lila
Lucas John
The Regents of the University of California
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