Antibodies that bind to endoglin

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241411, 4241301, 4241381, 5303871, 5303881, A61K 39395, C07K 1600

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active

056608276

ABSTRACT:
Disclosed are antibodies that specifically bind to endoglin. Conjugates of the antibodies linked to diagnostic or therapeutic agents are also provided. Methods of using the antibodies and conjugates are also disclosed, including methods of targeting the vasculature of solid tumors through recognition of the tumor vasculature-associated antigen, endoglin.

REFERENCES:
patent: 4456550 (1984-06-01), Dvorak et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 5021236 (1991-06-01), Gries et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
Burrows et al., "A Murine Model for Antibody-Directed Targeting of Vascular Endothelial Cells in Solid Tumors," Cancer Research, 52:5954-5962, Nov. 1992.
Burrows and Thorpe, "Targeting the Vasculature of Solid Tumors," Journal of Controlled Release, 28:195-202, Jan. 1994.
Clauss et al., "A Polypeptide Factor Produced by Fibrosarcoma Cells That Induces Endothelial Tissue Factor and Enhances the Procoagulant Response to Tumor Necrosis Factor/Cachetin," The Journal of Biological Chemistry, 265(12):7078-7083, Apr. 1990.
Thorpe and Burrows, "Antibody-Directed Targeting of the Vasculature of Solid Tumors," Breast Cancer Research and Treatment, 36(2):237-251, 1995.
Yamazaki et al., "Bispecific Monoclonal Antibodies with Specificities for Activated Platelets and Thrombolytic Agents, Their Production and Use," Abstract for Canadian Patent Application CA 2039259; Chem Abstracts, 117(11), Abstract #109988.
Osborn et al., "Leukocyte Adhesion to Endothelium in Inflammation," Cell, 62:3-6, 1990.
June et al., "Role of the CD28 Receptor in T-Cell Activation," Immunology Today, 11(6):211-216, 1990.
Denekamp, "Vascular Attack as a Therapeutic Strategy for Cancer," Cancer and Metastasis Reviews, 9:267-282, 1990.
Scott et al., "Anti-CD3 Antibody Induces Rapid Expression of Cytokine Genes In Vivo," The Journal of Immunology, 145(7):2183-2188, 1990.
O'Connell & Edidin, "A Mouse Lymphoid Endothelial Cell Line Immortalized by Simian Virus 40 Binds Lymphocytes and Retains Functional Characteristics of Normal Endothelial Cells," The Journal of Immunology, 144(2):521-525, 1990.
Ledbetter et al., "CD 28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction," Abstract only, Blood, 75(7):1531-1539, 1990.
Watanabe et al., "Exogenous Expression of Mouse Interferon .gamma. cDNA in Mouse Neuroblastoma C1300 Cells Results in Reduced Tumorigenicity by Augmented Anti-Tumor Immunity," Proceedings of the National Academy of Scientists, 86:9456-9460, 1989.
Schutt et al., "Human Monocyte Activation Induced by an Anti-CD14 Monoclonal Antibody," Immunology Letters, 19:321-328, 1988.
Thorpe et al., "Improved Antitumor Effects of Immunotoxins Prepared with Deglycosylated Ricin A-Chain and Hindered Disulfide Linkages," Cancer Research, 48:6396-6403, 1988.
Glennie et al., "Preparation and Performance of Bispecific (F(ab'.gamma.).sub.2 Antibody Containing Thioether-Linked Fab'.gamma. Fragments," The Journal of Immunology, 139(7):2367-2375, 1987.
Bevilacqua, et al., "Identification of an Inducible Endothelial-Leukocyte Adhesion Molecule," Proceedings of the National Academy of Scientists, 84:9238-9242, 1987.
Cotran et al., "Induction and Detection of a Human Endothelial Activation Antigen In Vivo," Abstract only, The Journal of Experimental Medicine, 164(2):661-666, 1986.
Groenewegen et al., "Lymphokine Dependence of In Vivo Expression of MHC Class II Antigens by Endothelium," Nature, 316:361-263, 1985.
Moretta et al., Abstract only, The Journal of Experimental Medicine, 162(3):823-838, 1985.
Vaickus & Foon, "Overview of Monoclonal Antibodies in the Diagnosis and Therapy of Cancer," Cancer Investigation, 93(2):295-209, 1991.
Hagemeier et al., "A Monoclonal Antibody Reacting with Endothelial Cells of Budding Vessels in Tumors and Inflammatory Tissues, and Non-Reactive with Normal Adult Tissues," International Journal of Cancer, 38:481-488, 1986.
Duijvestijn et al., "Lymphoid Tissue-and Inflammation-Specific Endothelial Cell Differentiation defined by Monoclonal Antibodies," The Journal of Immunology, 138(3):713-719, 1987.
Murray et al., "Vascular Markers for Murine Tumours," Radiotherapy and Oncology, 16:221-234, 1989.
Schlingemann et al., "Monoclonal Antibody PAL-E Specific for Endothelium," Laboratory Investigation, 52(1):71-76, 1985.
Bruland et al., "New Monoclonal Antibodies Specific for Human Sarcomas," International Journal of Cancer, 38:27-31, 1986.
Reisfeld et al., "Human Tumor-Associated Antigens Defined by Monoclonal Antibodies," CRC Critical Reviews in Immunology, 5(1):27-53, 1984.
Schlom et al., "Monoclonal Antibodies Reactive with Breast Tumor-Associated Antigens," Advances in Cancer Research, 43:143-173, 1985.
Kaplan, "The Diagnostic and Therapeutic Use of Monoclonal Antibodies in Colorectal Cancer," Hematology/Oncology Clinics of North American, 3(1):125-134, 1989.
Smith & Teng, "Clinical Applications of Monoclonal Antibodies in Gynecologic Oncology," Cancer, 60:2068-2074, 1987.
Stavrou, "Monoclonal Antibodies in Neuro-Oncology," Neurosurgery Review, 13:7-18, 1990.
Shepard et al., "Monoclonal Antibody Therapy of Human Cancer: Taking the HEr2 Protooncogene to the Clinic," Journal of Clinical Immunology, 11(3):117-127, 1991.
Szymendera, "Clinical Usefulness of Three Monoclonal Antibody-Defined Tumor Markers: CA 19-9, CA 50, and CA 125," Tumour Biology, 7:333-342, 1986.
Catane & Longo, "Monoclonal Antibodies for Cancer Therapy," Israel Jorunal of Medical Sciences, 24:471-476, 1988.
Greiner et al., "Applications of Monoclonal Antibodies and Recombinant Cytokines for the Treatment of Human Colorectal and Other Carcinomas," Journal of Surgical Oncology Supplement, 2:9-13, 1991.
Thor & Edgerton, "Monoclonal Antibodies Reactive with Human Breast or Ovarian Carcinoma: In Vivo Applications," Seminars in Nuclear Medicine, 19(4):295-308, 1989.
Thorpe et al., "Selective Killing of Proliferating Vascular Endothelial Cells by an Anti-Fibronectin Receptor Immunotoxin," 16th LH Gray Conference, University of Manchester Institute of Science and Technology, Sep. 17-21, 1990.
Thorpe et al., "Targeting To Proliferating Vascular Endothelium," International Symposium on Angiogenesis, St. Gallen, Switzerland, Abstract, Mar. 13-15, 1991.
Ghose, Tarun I. et al., "Preparation of Antibody-Linked Cytotoxic Agents," Methods in Enzymology, 93:280-333, 1983.
Knowles, Phillip P. and Thorpe, Philip E., "Purification of Immunotoxins Containing Ricin A-Chain and Abrin-A-Chain Using Blue Sepharose CL-6B," Analytical Biochemistry, 160:440-443, 1987.
Wang, Theodore S.T. et al., "Photoreactive In-Cyclodextrin Inclusion Complex: a New Heterobifunctional Reagent for Antibody Labeling," Nuclear Medicine and Biology, 19(8):897-902, 1992.
PCT Search Report mailed Jun. 25, 1993.
Alvarez, J.A. et al., "Localization of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor in Human Glial Neoplasms," Modern Pathology, 5(3):303-307, 1992.
Brown, Lawrence F. et al., "Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) and Its Receptors in Adenocarcinomas of the Gastrointestinal Tract," Cancer Research, 53:4727-4735, 1993.
Kim, K. Jin et al., "Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo," Nature, 362:841-843, 1993.
Dvorak, Harold F. et al., "Distribution of Vascular Permeability Factor (Vascular Endothelial Growth Factor) in Tumors: Concentration in Tumor Blood Vessels," J. Exp. Med., 174:1275-1278, 1991.
Gerlach, Herwig et al., "Enhanced Responsiveness of Endothelium in the Growing/Motile State to Tumor Necrosis Factor/Cachetin," J. Exp. Med., 170:913-931, 1989.
Gougos, Anne et al., "Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and synctiotrophoblasts," International Immunology, 4(1):83-92, 1991.
Gougos, Anne et al., "Identification of a Human Endothelial Cell Antigen with Monoclonal Antibody 44G4 Produced Against a Pre-B Leukemic Cell Line," The Journal of Immunology, 141:1925-1933, 1988.
Gougos, Anne et al., "Biochemical Characterizatio

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