Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Reexamination Certificate
2011-01-18
2011-01-18
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
C424S141100, C424S145100, C424S158100, C424S133100, C530S387300, C530S387900, C530S388100, C530S388240, C530S399000
Reexamination Certificate
active
07871617
ABSTRACT:
The present invention relates to antibodies that bind to a portion of the Von Willebrand's factor (VWC) domain of connective tissue growth factor (CTGF). The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
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Duncan et al. (1999) Connective Tissue Growth Factor Mediates Transforming Growth Factor beta-induced Collagen Synthesis: Down Regulation by cAMP. FASEB J 13:1774-1786.
Usinger et al. (2003) TGFbeta2 Binds CTGF Specifically and is Inhibited by a CTGF Neutralizing Antibody, FG-3019. J Am Soc Nephrol 14:374A.
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Lin Al Y.
Neff Thomas B.
Oliver Noelynn A.
Usinger William R.
Wang Qingjian
Fibrogen Inc.
Spector Lorraine
Turner Christopher
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