Antibodies that bind to a ligand-induced binding site on integri

Details Antibodies that bind to a ligand-induced binding site on integri Antibodies that bind to a ligand-induced binding site on integri

1990-11-13

1994-04-26

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436 63, 436548, 436811, G01N 33567

Patent

active

053066200

ABSTRACT:
An integrin-activating antibody is disclosed that immunoreacts with an integrin and when immunoreacted increases the binding affinity of the integrin for binding to ligands specific for the integrin. The antibody also immunoreacts with a ligand-induced binding site (LIBS) on the integrin when the integrin is specifically bound to its ligand. Further disclosed are therapeutic compositions and methods for promoting cell adhesion using the disclosed integrin-activating antibodies.

REFERENCES:
patent: 5114842 (1992-05-01), Plow et al.
Kouns et al., J. Biol. Chem. 265:20594-20601, 1990.
Frelinger et al., J. Biol. Chem 263:12397-12402, 1988.
Jennings et al., Blood 65:1112-1119, 1985.
Frelinger, et al., J. Cell Biol. 107: 386a, abst. No. 2199 (1988).
Frelinger et al., J. Biol. Chem. 265: 6346-6352 (1990).
Ginsberg et al., J. Biol. Chem. 262: 5437-5440 (1987).
Shadle et al., J. Cell. Biol. 99: 2056-2060 (1984).
Ginsberg et al., J. Clin. Invest. 78: 1103-1111 (1986).
Shattil et al., J. Biol. Chem. 260: 11107-11114 (1985).
Shattil et al., J. Biol. Chem. 262: 992-1000 (1987).
Coller, B. S., J. Cell Biol. 103: 451-456 (1986).
D'Souza et al., J. Biol. Chem. 265: 3440 (1990).
Wright et al., J. Immunol. 136: 1759-1764 (1986).
Detmers et al., J. Cell Biol. 105: 1137-1145 (1987).
Altieri et al., J. Cell. Biol. 107: 1893-1900 (1988).
Phillips et al., J. Clin. Invest. 82:495-501 (1988).
Buyon et al., J. Immunol. 140: 3156-3160 (1988).

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