Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-02-15
2011-02-15
Wen, Sharon (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S387300, C530S387900, C530S388100, C424S130100, C424S133100, C424S134100, C424S135100, C424S141100, C424S143100, C435S326000, C435S070100
Reexamination Certificate
active
07888482
ABSTRACT:
The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides antibodies that bind human PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.
REFERENCES:
patent: 5716789 (1998-02-01), Sundelin et al.
patent: 5874400 (1999-02-01), Sundelin et al.
patent: 2002/0037860 (2002-03-01), D'Andrea et al.
patent: 0 804 452 (2001-09-01), None
patent: WO 01/52883 (2001-07-01), None
patent: WO 2004/080373 (2004-09-01), None
patent: WO 2009/117481 (2009-09-01), None
patent: WO 2010/017086 (2010-02-01), None
Todorovska et al. JIM 2001, 248:47-66.
Ward et al. Nature 1989, 341:544-546.
Green JIM 1999 231:11-23.
Owens et al. JIM, 1994, 168:149-165.
Bloom Protein Sci. 1997, 6:407-415.
Falkenberg J. Clin. Chem. Clin. Biochem. 1984, 22:867-882.
Nakayama et al. Brit. J. Pharm. 2003, 138:121-130.
Campbell Monoclonal Antibody Technology, 1984, Chapter 1, pp. 1-32.
Molino et al., “Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells,”Arterioscler Thromb Vasc Biol, 18:825-832, 1998.
Sullivan, E. et al., Measurement of [Ca2+] using the fluorometric imaging plate reader (FLIPR),Methods Mole. Bio., 114:125-133, 1999.
D'Andrea et al., “Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues,”J. Histochem . Cytochem. 46(2): 157-164, 1998.
Ferrell, et al., “Essential role for proteinase-activated receptor-2 in arthritis,” J. Clin. Invest. 111(1): 35-41, 2003.
Kelso et al., “Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation,”J. Pharmacol. Exp. Ther. 316(3): 1017-1024, 2006.
Koo et al., “Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of Par-2,”FEBS Letters523: 85-89, 2002.
Maeda et al., “Proinflammatory role of trypsin and protease-activated receptor-2 in a rat model of acute pancreatitis,”Pancreas31(1): 54-62, 2005.
McGuire et al., “2-Furoyl-LIGRLO-amide: A potent and selective proteinase-activated receptor 2 agonist,”J Pharmacol Exp. Ther. 309(3): 1124-1131, 2004.
Molino et al., “Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells,”Arterioscler. Thromb. Vasc. Biol.18: 825-832, 1998.
Nystedt et al., “Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2,”Eur. J. Biochem. 232: 84-89, 1995.
Saifeddine et al., “Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue,”Br. J. of Pharmacology118: 521-530, 1996.
Schmidlin, et al., “Protease-activated receptor 2 mediates eosinophil infiltration and hyperactivity in allergic inflammation of the airway,”J. Immunol. 169: 5315-5321, 2002.
Seeliger et al., “Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo,”FASEB J. 17: 1871-1885, 2003.
Wang et al., “Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated receptor 2,”Radiat. Res. 160: 524-535, 2003.
PAR-2 (SAM11) Antibody sc 13504, Santa Cruz Biotechnology, Inc., 2 pages, 2006.
Hu Shaw-Fen Sylvia
Virca George Duke
Amgen Inc.
Perkins Patricia Anne
Wen Sharon
LandOfFree
Antibodies that bind PAR-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies that bind PAR-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies that bind PAR-2 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2637687