Antibodies that bind novel carbohydrate ligands (myelorollins) t

Details Antibodies that bind novel carbohydrate ligands (myelorollins) t Antibodies that bind novel carbohydrate ligands (myelorollins) t

1996-04-22

1999-03-02

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

514 54, 5303875, A61K 39395, C07K 1600

Patent

active

058767150

ABSTRACT:
The invention relates to antibodies that specifically bind a myelorollin comprising an unbranched polylactosamine comprising at least 10 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except the penultimate N-acetylglucosamine residue. The invention also relates to a method of using such antibodies to inhibit E-selectin-dependent rolling of a cell on another cell, wherein one of the cells expresses a myelorollin that binds the antibodies.

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