Antibodies that bind human Dickkopf-1 proteins

Details Antibodies that bind human Dickkopf-1 proteins Antibodies that bind human Dickkopf-1 proteins

2004-04-06

2008-11-04

Romeo, David S (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387300, C530S388100, C530S388150, C530S389100, C530S389200, C530S391300, C530S866000

Reexamination Certificate

active

07446181

ABSTRACT:
The invention relates to antibodies and immunologically active portions thereof that selectively bind a human Dickkopf-1 (Dkk-1) or Dkk-1-related polypeptide, and to compositions that contain such antibodies and/or immunologically active portions.

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U.S. Appl. No. 09/009,802, filed Jan. 20, 1998, Sean A. McCarthy.
Aravind, L. and Koonin, E.V., “A colipase fold in the carboxy-terminal domain of the Wnt antagonists- the Dickkopfs,”Curr. Biol., 8(14):R477-8 (1998).
Austin, T.W. et al., “A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells,” Blood 89(10):3624-3635 (1997).
Barton, “Protein sequence alignment and database scanning,” inProtein Structure Predicition, A Practical Approach(IRL Press, Oxford University Press, Oxford, UK, pp. 31-63 (Jan. 1997).
Bowie et al., “Deciphering the message in protein sequences: tolerance to amino acid substitutions,”Science, 247(4948): 1306-1310 1990).
Cadigan, K.M. et al., “Wnt signaling: A common theme in animal development,”Genes&Development, 11:3286-3305 (1997).
Fedi, P. et al., “Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling,”J. Biol. Chem., 274(27):19465-19472 (1999).
Finch, P.W. et al., “Purification and molecular cloning of a secreted, Fizzled-related antagonist of Wnt action,”Proc. Natl. Acad. Sci. USA, 94(13):6770-6775 (1997).
GenBank™ Accession No. 2724106 for RIG-like 7-1 [Homo sapiens] (1997).
GenBank™ Accession No. 2736292 for mdkk-1 [Mus musculus] (1998).
GenBank™ Accession No. 2736294 for Xdkk-1 [Xenopus laevis] (1998).
GenBank™ Accession No. 3660556 for hdkk-4 [Homo sapiens] (1998).
GenBank™ Accession No. 3688630 for hdkk-4 [Homo sapiens] (1998).
GenBank™ Accession No. A39976 for Sequence 9 from Patent WO942179 (1997).
GenBank™ Accession No. AA 018255 for Soares retina N2b4HRHomo sapienscDNA clone 361535 5′, mRNA sequence (1996).
GenBank™ Accession No. AA031969 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone 470646 3′, mRNA sequence (1996).
GenBank™ Accession No. AA032060 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:470646 5′,mRNA sequence (Aug. 21, 1996).
GenBank™ Accession No. AA035345 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:471479 3′, mRNA sequence (1997).
GenBank™ Accession No. AA035443 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:471724 3′, mRNA sequence (1997).
GenBank™ Accession No. AA035583 for Soares—pregnant—uterus—NbHPUHomo sapiensclone IMAGE:471724 5′, mRNA sequence (1997).
GenBank™ Accession No. AA037322 for Soares—senescent—fibroblasts—NbHSFHomo sapienscDNA clone 325915 5′, mRNA sequence (1996).
GenBank™ Accession No. AA041360 for Soares—fetal—heart—NbHH19WHomo sapienscDNA clone 376472 3′, mRNA sequence (1997).
GenBank™ Accession No. AA042806 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:486515 3′, mRNA sequence (1996).
GenBank™ Accession No. AA043027 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:486515 5′, mRNA sequence (1996).
GenBank™ Accession No. AA063859 for Stratagene mouse testis (#937309)Mus musculuscDNA clone 514640 5′ similar to TR:G517093 G517093 Hypothetical 39.2 KD Protein; mRNA sequence (1997).
GenBank198 Accession No. AA065307 for Testis 5Homo sapienscDNA clone a03500 5′ end, mRNA sequence (1996).
GenBank™ Accession No. AA073904 for Stratagene mouse heart (#937316)Mus musculuscDNA clone 536577 5′, mRNA sequence (1997).
GenBank198 Accession No. AA088618 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:487642 5′, mRNA sequence (1996).
GenBank™ Accession No. AA107210 for Stratagene mouse testic (#937308)Mus musculuscDNA clone IMAGE:516168 5′ similar to TR:G517093 G517093 Hypothetical 39.2 kd protein; mRNA sequence (1997).
GenBank™ Accession No. AA115249 for Soares—pregnant-uterus-NbHPUHomo sapienscDNA clone IMAGE:501425 3′, mRNA sequence (1997).
3GenBank™ Accession No. AA115337 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA—clone 501425 5′, mRNA sequence (1997).
GenBank™ Accession No. AA129488 for Stratagene lung carcinoma 937218Homo sapienscDNA clone IMAGE:564360 3′, mRNA sequence (1997).
GenBank™ Accession No. AA136192 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:490113 5′, mRNA sequence (1996).
GenBank™ Accession No. AA137219 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:490113 3′, mRNA sequence (1996).
GenBank™ Accession No. AA143670 for Stratagaene pancreas (#937208)Homo sapienscDNA clone IMAGE:591770 5′, mRNA sequence (1996).
GenBank™ Accession No. AA155928 for Stratagene endothelial cell 937223Homo sapienscDNA clone 590026 5′, mRNA seqence (1996).
GenBank™ Accession No. AA207078 for NCI—CGAP—GCB1Homo sapienscDNA clone IMAGE:682716 5′, mRNA sequence (1997).
GenBank™ Accession No. AA209468 for Stratagene hNT neuron (#937233)Homo sapienscDNA clone 648310 3′, mRNA sequence (1998).
GenBank™Accession No. AA220766 for Soares mouse 3NME12 5Mus musculuscDNA clone IMAGE:660068 5′, mRNA sequence (1997).
GenBank™ Accession No. AA237194 for Soares mouse NMLMus musculuscDNA clone IMAGE:678567 5′ similar to gb:U11248 Mus musculus C57BL/6J ribosomal protein S28 mRNA, complete (MOUSE), mRNA sequence (1997).
GenBank™ Accession No. AA253446 for Soares—NhHMPu—S1Homo sapienscDNA clone IMAGE:669375 5′, mRNA sequence (1997).
GenBank™ Accession No. AA253464 for Soares—NhHMPu—S1Homo sapienscDNA clone 669375 3′, mRNA sequence (1997).
GenBank™ Accession No. AA259742 for Soares mouse 3NME12 5Mus musculuscDNA clone IMAGE:734543 5′ similar to gb:U11248Mus musculusC57BL/6J ribsomal protein S28 mRNA, complete (MOUSE), mRNA sequence (1997).
GenBank™ Accession No. AA265561 for Soares mouse lymph node NbMLNMus musculuscDNA clone 718668 5′ similar to TR:G517093 G517093 Hypothetical 39.2 KD Protein; mRNA sequence (1997).
GenBank™ Accession No. AA269333 for Soares mouse 3NME12 5Mus musculuscDNA clone IMAGE:733911 5′, mRNA sequence (1997).
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