Antibodies that bind hepatocyte growth factor activator

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S388100, C530S391700, C530S350000, C424S133100

Reexamination Certificate

active

07825221

ABSTRACT:
The invention provides methods and compositions for modulating hepatocyte growth factor activator function.

REFERENCES:
patent: 5466593 (1995-11-01), Shimomura et al.
patent: 6407213 (2002-06-01), Carter et al.
patent: 7045602 (2006-05-01), Naka et al.
patent: 1 213 302 (2002-06-01), None
Mould et al. The Inhibitory Anti-b1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy. J. Biol. Chem., 1996, 271:20365-20374.
Birchmeier et al., “Met, Metastasis, Motility and More”Nature Reviews Molecular Cell Biology4:915-925 (Dec. 2003).
Cao, Brian et al., “Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models”Proc. Natl. Acad. Sci. USA98(13):7443-7448 (Jun. 19, 2001).
Delaria et al., “Characterization of placental bikunin, a novel human serine protease inhibitor”J Biol Chem. 272(18):12209-12214 (May 2, 1997).
Dennis and Lazarus, “Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa, II. Potent and Specific Inhibitors by Competitive Phage Selection”Journal of Biological Chemistry269(35):22137-22144 (Sep 2, 1994).
Dennis et al., “Peptide Exosite Inhibitors of Factor VIIa as Anticoagulants”Nature404(6777):465-470 (Mar. 30, 2000).
Dickinson et al., “Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa”Proc. Natl. Acad. Sci USA93(25):14379-14384 (Dec. 10, 1996).
Dickinson at al., “Influence of Cofactor Binding and Active Site Occupancy on the Conformation of the Macromolecular Substrate Exosite of Factor VIIa”J. Mol. Biol.277:959-971 (1998).
Gak et al., “Processing of Hepatocyte Growth Factor to the Heterodimeric Form is Required for Biological Activity”FEBS Letters311(1):17-21 (Oct. 1992).
Hartmann et al., “A Functional Domain in the Heavy Chain of Scatter Factor/Hepatocyte Growth Factor Binds the c-Met Receptor and Induces Cell Dissociation but Not Mitogenesis”Proc. Natl. Acad. Sci. USA89(23):11574-11578 (Dec. 1, 1992).
Kataoka et al., “Activation of Hepatocyte Growth Factor/Scatter Factor in Colorectal Carcinoma”Cancer Research60:6148-6159 (Nov. 1, 2000).
Kawaguchi et al., “Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor”J Biol Chem.272(44):27558-27564 (Oct. 31, 1997).
Kirchhofer et al,, “Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1”J Biol Chem. 278(38):36341-36349 (Sep. 19, 2003).
Lee et al., “High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold”J Mol Biol. 340(5):1073-1093 (Jul. 23, 2004).
Lin et al., “Purification and characterization of a complex containing matriptase and a kunitz-type serine protease inhibitor from human milk”J Biol Chem274(26).18237-18242 (Jun. 25, 1999).
Lokker et al., “Structure-Function Analysis of Hepatocyte Growth Factor: Identification of Variants that Lack Mitogenic Activity Yet Retain High Affinity Receptor Binding”EMBO Journal11(7)-2503-2510 (1992).
Marlor et al., “Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains”J Biol Chem. 272(18) 12202-12208 (May 2, 1997).
Miyazawa et al., “Activation of Hepatocyte Growth Factor in the Injured Tissues Is Mediated by Hepatocyte Growth Factor Activator”Journal of Biological Chemistry271 3615-3618 (1996).
Miyazawa et al., “Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor”Journal of Biological Chemistry268(14):10024-10028 (May 15, 1993).
Mould, Paul, A., et al., “The inhibitory anti-β 1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy”The Journal of Biological Chemistry271(34):20365-20374(Aug. 1996).
Naka at al., “Activation of Hepatocyte Growth Factor by Proteolytic Conversion of a Single Chain Form to a Heterodimer”The Journal of Biological Chemistry267(28):20114-20119 (Oct. 5, 1992).
Peek et al., “Unusual Proteolytic Activation of Pro-hepatocyte Growth Factor by Plasma Kallikrein and Coagulation Factor XIa”Journal of Biological Chemistry277(49):47804-47809 (Dec. 6, 2002).
Shimomura et al., “Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor”Journal of Biological Chemistry272(10):6370-6376 (Mar. 7, 1997).
Shimomura, Takeshi, et al., “Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator”European Journal of Biochemistry229(1):257-261 (Feb 1995).
Trusolino & Comoglio, “Scatter-Factor and Semaphorin Receptors: Cell Signalling for Invasive Growth”Nature Rev. Cancer2(4):289-300 (Apr. 2002).
Wu, Yan, et al., “Structural insight into distinct mechanisms of protease inhibition by antibodies”Proc. Natl. Acad. Sci. USA104(50):19784-19789 (Dec. 11, 2007).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antibodies that bind hepatocyte growth factor activator does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies that bind hepatocyte growth factor activator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies that bind hepatocyte growth factor activator will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4189488

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.