Antibodies that bind gamma-heregulin

Details Antibodies that bind gamma-heregulin Antibodies that bind gamma-heregulin

2005-07-12

2005-07-12

Keimmerer, Elizabeth (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S971000, C530S399000, C530S388230, C530S389100, C530S387100, C530S388100, C530S389200

Reexamination Certificate

active

06916624

ABSTRACT:
A novel member of the heregulin superfamily has been identified which is designated “γ-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. γ-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of γ-HRG nucleic acid for the recombinant production of γ-HRG). γ-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.

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Plowman

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