Antibodies that are immunoreactive with interleukin-4 receptors

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303879, 5303896, 4241391, 4241441, 4241721, 435334, 435 7021, 4351722, A61K 39395

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057170720

ABSTRACT:
Mammalian antibodies that are immunoreactive with Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, as well as antibodies that are immunoreactive with IL-4 receptors. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, involves administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

REFERENCES:
patent: 4551433 (1985-11-01), DeBoer
patent: 4675285 (1987-06-01), Clark et al.
patent: 4683199 (1987-07-01), Palladino
patent: 5449756 (1995-09-01), Taniguchi et al.
Chester et al. 1995 TibTech vol. 13: 294-300.
Paul WB 1993 Fundamental Immunology Raven Press NY Ch 21 p. 826.
Ohara and Paul, "Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage", Nature 325:537-540, 1987.
Park et al., "Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1", Proc. Nat. Acad. Sci. USA, 84:1669-1673, 1987.
Park et al., "Characterization of the Human B Cell Stimulatory Factor 1 Receptor", J. Exp. Med., 166:476-488, 1987.
Nakajima et al., "Detection of Receptors for Murine B Cell Stimulatory Factor 1 (BSF1): Presence of Functional Receptors on CBA/N Splenic B Cells", J. Immunol. 139:774-779, 1987.
Cabrillat et al., "High Affinity Binding of Human Interleukin 4 to Cell Lines", Biochem. & Biophys. Res. Commun. 149:995-1001, 1987.
Lowenthal et al., "Expression of High Affinity Receptors for Murine Interleukin 4 (BSF1)", J. Immunol. 140:456-464, 1988.
Lowenthal et al., "Up-Regulation of Interleukin 4 Receptor Expression of Immature (Lyt-2.sup.- /L3T4.sub.-) Thymocytes", J. Immunol. 140:474-478, 1988.
Park et al., "Interleukin-4 Binds to Murine Fibroblasts: Receptor Characterization and Induction of Colony Stimulating Activity Production", UCLA Symposia Abstracts, J. Cell Biochem. Suppl. 12A, 1988.
Dower et al., "Interleukin Receptors", ISI Atlas of Science: Immunology, 116-120, 1988.
Okayama and Berg, "High-Efficiency Cloning of Full-Length cDNA", Mol. Cell. Biol. 2:161-170, 1983.
Okayama and Berg, "A cDNA Cloning Vector that Permits Expression of cDNA Inserts in Mammalian Cells", Mol. Cell. Biol. 3:280-289, 1983.
Aruffo and Seed, "Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system", Proc. Natl. Acad. Sci. USA 84:8573-8577, 1987.
Yamasaki et al., "Cloning and Expression of the Human Interleukin-6 (BSF-2/IFN.beta. 2) Receptor", Science 241:825-828, 1988.
Sims et al., "cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily", Science 241:585-589, 1988.
De Maagd et al., "The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies", Immunology 54:745-754, 1985.
Larche et al., "A novel T-lymphocyte molecule that may function in the induction of self-tolerance and MHC-restriction within the human thymic microenvironment", Immunology 64:101-105, 1988.
Larche et al., "Functional evidence for a monoclonal antibody that binds to the human IL-4 receptor", Immunology 65:617-622, 1988.
Jabaari et al., British J. Cancer 59 (6) 910-914, 1989.
Solari et al, Biochem. J. 262:897-908, 1989.
Urdal et al., "Studies on Hematopoietic Growth Factor Receptors Using Human Recombinant IL-3, GM-CSF, G-CSF, M-CSF, IL-1 and IL-4", Behring Inst. Mitt. 83:27-39, Aug., 1988.
Harada et al., "Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding", Proc. Natl. Acad. Sci. USA 87:857-861, 1990.
Mosley et al., "The Murine Interleukin-4 Receptor: Molecular Cloning and Characterization of Secreted and Membrane Bound Forms", Cell 59:335-348, Oct., 1989.
Finkelman et al., "IL-4 Is Required to Generate and Sustain In Vivo IgE Responses", J. Immunol. 141:2335-2341, 1988.
Finkelman et al., "Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1", Proc. Natl. Acad. Sci. USA 83:9675-9678, 1986.
Snapper et al., "Differential Regulation of IgG1 and IgE Synthesis by Interleukin 4", J. Exp. Med. 167:183-196, 1988.
Finkelman et al., "T Help Requirements for the Generation of an In Vivo IgE Response: A Late Acting Form of T Cell Help Other Than IL-4 Is Required for IgE but not for IgG1 Production", J. Immunol. 142:403-408, 1989.
Galizzi et al., "Purification of a 130-kDa T Cell Glycoprotein That Binds Human Interleukin 4 with High Affinity", J. Biol. Chem. 265:439-444, 1990.
Galizzi et al., "Internalization of Human Interleukin 4 and Transient Down-regulation of Its Receptor in the C23-inducible Jijoye Cells", J. Biol. Chem. 264:6984-6989, 1989.

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