Antibodies specifically reactive with thrombin receptor and its

Details Antibodies specifically reactive with thrombin receptor and its Antibodies specifically reactive with thrombin receptor and its

1995-06-07

1999-01-05

Huff, Sheela

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530381, 5303879, 5303891, 5303893, 53038825, 530837, 4241391, 4241431, C07K 1600, C12P 2108

Patent

active

058564489

ABSTRACT:
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists and antagonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.

REFERENCES:
patent: 4783330 (1988-11-01), Furie
patent: 4859609 (1989-08-01), Dull et al.
patent: 5256766 (1993-10-01), Coughlin
Campbell, Monoclonal Antibody Technology, Elsievers Science Publishers p. 1-32 1986.
Waldmann Science vol. 252 p. 1657 Jun. 1991.
Harris et al, TIBTECH vol. 11 p. 42 Feb. 1993.
Baniyash et al., J. Biol. Chem.,vol. 264, pp. 13252-13257 (1989).
Bar-Shavit et al., Journal of Cell Biology,vol. 112(2), pp. 335-344 (1991).
Berndt et al., Elsevier/North Holland Biomedical Press,pp. 43-74, "Platelets in Biology and Pathology" (1981).
Bode et al., EMBO Journal,vol. 8, pp. 3467-3475 (1989).
Edington, Biotechnology,vol. 10, pp. 383-389 (1992).
Foster et al., id.,vol. 82, pp. 4673-4677 (1985).
Frost et al., J. Cell. Biol.,vol. 105, pp. 2551-2558 (1987).
Gearing et al., EMBO Journal,vol. 8, pp. 3667-3676 (1989).
Greco et al., Blood,vol. 75, pp. 1983-1990 (1990).
Gronke et al., J. Biol. Chem.,vol. 262, pp. 3030-3036 (1987).
Hui et al., BBRC,vol. 184, pp. 790-796 (1992).
Jackman et al., Proc. Natl. Acad. Sci.,vol. 84, pp. 6425-6429 (1987).
Martin et al., Biochem.,vol. 14, pp. 1308-1314 (1975).
Masu et al., Nature,vol. 329 pp. 836-838 (1987).
Okamura et al., J. Biol. Chem.,vol. 253, pp. 3435-3443 (1978).
Phillips, Thrombin Diath. Haemorrh.,vol. 32, pp. 207-215 (1974).
Pipili-Synetos et al., Biochem. Biophys. Res. Comm.,vol. 171, pp. 913-919 (1990).
Tollefson et al., J. Biol. Chem.,vol. 249, pp. 2646-2651 (1974).
Rasmussen et al., FEBS Letters,vol. 288, pp. 123-128 (1991).
Ruda et al., Biochemical Pharmacology,vol. 39(2), pp. 373-381 (1990).
Ruda et al., Annals. New York Academy of Sciences,vol. 485, pp. 439-442 (1986).
Ruda et al., Biochemical Pharmacology,vol. 37(12), pp. 2417-2426 (1988).
Sambrook et al., Molecular Cloning, 2nd edition,Cold Spring Harbor (NY) Press, Ch. 12 (1990).
Sambrook et al., op. cit.,pp. 11.2-11.8 (1990).
Scarborough et al., J. Biol. Chem., vol. 267, pp. 13146-13149 (1992).
Seed et al., id.,vol. 84, pp. 3365-3369 (1987).
Sevier, Clin. Chem.,vol. 27, pp. 1797-1806 (1981).
Suzuki, Acta. Haematol.,vol. 51, pp. 1655-1664 (1988).
Van Obberghen-Schilling et al., FEBS Letters,vol. 262, pp. 330-334 (1990).
Vu et al., Nature,vol. 353, pp. 674-677 (1991).
Vu et al., Cell,vol. 64, pp. 1057-1068 (1991).
Walz et al., Annals. New York Academy of Sciences,vol. 485, pp. 323-334 (1986).
Watson et al., Recombinant DNA,2nd ed., New York, Scientific American, p. 108 (1989).
Workman et al., J. Biol. Chem.,vol. 252, pp. 7118-7123 (1977).
Young et al, Proc. Natl. Acad. Sci. USA,vol. 80, pp. 1194-1198 (1983).
D. Cosman, DNA and Protein Engineering Techniques,vol. 2, No. 1, pp. 1-3 (1990).
Yamamoto et al., Thrombosis and Haemostasis,vol. 55(2), pp. 162-167 (1986).

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