Antibodies specifically reactive with T-cadherin

Details Antibodies specifically reactive with T-cadherin Antibodies specifically reactive with T-cadherin

1995-06-07

1999-01-26

Hutzell, Paula K.

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

436548, 514 2, 514 8, 5303879, 5303881, 5303891, G01N 3353, C07K 1600

Patent

active

058638040

ABSTRACT:
The present invention provides antibodies specifically reactive with T-cadherin, but not with N-, E- or P-cadherin. The present invention also provides methods of obtaining such antibodies by administering to an animal a synthetic peptide or a recombinant protein fragment having a partial sequence of T-cadherin. The present invention further provides antibodies obtained by such methods.

REFERENCES:
Harlow et al "Antibodies: A Laboratory Manual", 1988 Cold Spring Harbor Press pp. 92-120 and 139-242.
Laemmti, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685 (1970).
Ranscht et al., A neuronal surface glycoprotein associated with the cytoskeleton, J. Cell. Biol. 99:1803-1813 (1984).
Edelman et al., Cellular expression of liver and neural cell adhesion molecules after transfection with their cDNAs results in specific cell-cell binding. Proc. Natl. Acad. Sci. USA 84:8502-8506 (1987).
Gallin et al., Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM. Proc. Natl. Acad. Sci. USA 84:2808-2812 (1987).
Hatta et al., Spatial and Temporal Expression Pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos. Dev. Biol. 120:215-217 (1987).
Nagafuchi et al., Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329:341-343 (1987).
Nose et al., Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules. EMBO J. 6(12):3655-3661 (1987).
Ringwald et al., The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca.sup.3+ -dependent cell adhesion. EMBO J. 6(12):3647 (1987).
Hatta et al., Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its Identity in the cadherin gene family. J. Cell Biol. 106:873-881 (1988).
Mege et al., Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules. Proc. Natl. Acad. Sci. USA 85:7274-7278 (1988).
Nagafuchi and Takeichi, Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J. 7(12):3679-3684 (1988).
Neugebauer et al., N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro. Chem. Abstract 109:487, abstract No. 109:167903c (1988).
Takeichi, The cacherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 102:639-655 (1988).
Kemler and Ozawa, Uvomorulin-catenin complex: cytoplasmic anchorage of a Ca.sup.2+ -dependent cell adhesion molecule. BioEssays 11(4):88-91 (1989).
Moss and White, A Ca.sup.3+ -sensitive glycoprotein, GP90, associated with the cytoskeleton from brain and gizzard. J. Cell Sci. 93:85-94 (1989).
Nagafuchi and Takeichi, Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin. Cell Regulation 1:37-44 (1989).
Ozawa et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8(6):1711-1717 (1989).
Ranscht and Dours, Selective Expression of a novel cadherin in the pathways of developing motor and commissural axons. Society for Neuroscience Abstracts 15(part 1), abstract No. 382.6 (1989).
Bixby and Zhang, Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J. Cell Biol. 110:1253-1260 (1990).
Matsuzaki et al., DNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells. J. Cell Biol. 110:1239-1252 (1990).
McNeill et al., Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell 62:309-316 (1990).
Nose et al., Localization of specificity determining sites in cadherin cell adhesion molecules. Cell 61:147-155 (1990).
Ozawa et al., Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. Natl. Acad. Sci. USA 87:4246-4250 (1990).
Ozawa and Kemler, Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin. J. Cell Biol. 111:1645-1650 (1990).
Ozawa et al., Single amino acid substitutions in one Ca.sup.2+ binding site of uvomorulin abolish the adhesive function. Cell 63:1033-1038 (1990).
Takeichi, Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem. 59:237-252 (1990).
Ranscht, Cadherin cell adhesion molecules in vertebrate neural development. Seminars in The Neurosciences 3:285-296 (1991).
Ranscht and Dours-Zimmermann, T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron 7:391-402 (1991).

Affiliated with

Also associated with

Rating

Antibodies specifically reactive with T-cadherin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies specifically reactive with T-cadherin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies specifically reactive with T-cadherin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1449956