Antibodies specific to human prostacyclin synthase

Details Antibodies specific to human prostacyclin synthase Antibodies specific to human prostacyclin synthase

2006-10-10

2006-10-10

Chan, Christina (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387900

Reexamination Certificate

active

07119176

ABSTRACT:
The present invention clarifies the primary structure of human-originated PGIS and the nucleotide sequence encoding same. The PGIS and its DNA are useful as reagents for the development of therapeutic agents for the cardiovascular diseases induced by the production imbalance between PGI2and TXA2, and as diagnostics for determining the in vivo tissue expression level and distribution of PGIS or mRNA thereof. Moreover, they can be used as therapeutic agents for cardiovascular diseases, which introduce PGIS and the like into human or other animals in a lesion-specific manner. The production method of the present invention is useful for the easy and efficient mass production of the human-originated PGIS. The antibody of the present invention is useful for the purification of the human-originated PGIS and immunohistochemical analysis of the cause of a disease.

REFERENCES:
Colman, Research in Immunology, 1994, 145(1):33-36.
Miyata et al. Biochem. Biophy. Res. Comm. 1994, 200(30):1728-1734.
Campbell, 1984, Monoclonal Antibody Technology, Elsevier Sc. Publishers, p. 1-32.
Kuby, Immunology, p. 14-15, W.H. Freeman Co. 4thEd,,2000.
Babette B. Weksler; Heparin and Acidic Fibroblast Growth Factor Interact to Decrease Prostacyclin Synthesis in Human Endothelial Cells by Affecting Both Prostaglandin H Synthase and Prostacyclin Synthase; J. Cell. Physiol., 142[3], p. 514-522, 1990.
Ngo et al. (1994) Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox. In: The Protein Folding Proble and Tertiary Structure Prediction, Eds. Merz et al., Birkhauser, Boston, MA pp. 491-495.
Weksler, Heparin and Acidic Fibroblast Growth Factor Interact to Decrease Prostacyclin Synthesis in Human Endothelial Cells by Affecting Both Prostaglandin H Synthase and Prostacyclin Synthase;J. Cell. Physiol.,142(3):514-522 (1990).
Hara et al., Isolation and Molecular Cloning of Prostacyclin Synthase from Bovine Endothelial Cells,J. Biol. Chem.269:19897-19903 (1994).
Smith et al., Bimodal Distribution of the Prostaglandin I2Synthase Antigen in Smooth Muscle Cells,J. Biol. Chem.,258(9):5922-5926 (1983).
Smith et al., Purification, Quantitation, and Localization of PGI2Synthase Using Monoclonal Antibodies,Adv Prostaglandin Thromboxane Leukot Res.11:87-92 (1983).
S. Moncada, Eighth Gaddum Memorial Lecture. University of London Institute of Education, Dec. 1980. Biological importance of prostacyclin.Br J Pharmacol.76(1):3-31 (1982).
Gorman et al., Agonist-Specific Desensitization of PGI2-Stimulated Cyclic AMP Accumulation by PGE1In Human Foreskin Fibroblasts,Prostaglandins, 19(1):2-16 (1980).
Cytochrome P-450, Biochemistry, Biophysics and Environmental Implications, Proceedings of the 4thInternational Conference on Cytochrome P-450 held in Kuopio, Finland, May 31-Jun. 3, 1992, E. Hietanen et al., eds., pp. 103-106, 1982.
DeWitt et al., Purification of Prostacyclin Synthase from Bovine Aorta By Immunoaffinity Chromatography,J. Biol. Chem.,258(5):3285-93 (1983).
M. Inoue, Molecular Characterization of the Prostacyclin Synthase,Adv Prostaglandin Thromboxane Leukot Res.17A:29-33 (1987).
Pereira et al., Bovine Prostacyclin Synthase: Purification and Isolation of Partial cDNA,Biochem. Biophys. Res. Comm.197(3):1041-1048 (1993).
T. Shimizu, Structure-function relationships of membrane-bound heme-enzyme, cytochrome P450, Institute for Chemical Reaction Science, Tohoku University, pp. 10-15, 1992.
Salmon et al., Preparation and Assay of Prostacyclin Synthase, Methods in Enzymology, 86:91-99 (1982).
Tanabe et al., Molecular Cloning of Prostacyclin Synthase From Bovine Endothelial Cells, in Eicosandoids & Other BioActive Lipids in Cancer, Inflammation and Radiation Injury, 3rdInt'l Conf., Georgetown Conference Center, Washington D.C., pp. 137, Oct. 13-16, 1993.
Tanabe et al., Advances in Prostaglandin, Thromboxany and Leukotriene Research, vol. 23, 1995, pp. 133-135.
Govindarajan et al, Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome.Hepatology7(4):654-659 (1987).
Keirse et al., Does or can human placenta produce prostacyclin?Placenta7(1):37-42 (1986).
Siegle et al, Characterization of monoclonal antibodies generated against bovine and porcine prostacyclin synthase and quantitation of bovine prostacyclin synthase,FEBS lett.347(2-3):221-5 (1994).
Dewitt et al., Monoclonal antibodies against PG12 synthase: an immunoradiometric assay for quantitating the enzyme.Methods Enzymol.86:240-246 (1982).
Moonen et al., Immunohistochemical localisation of prostaglandin endoperoxide synthase and prostacyclin synthase in pregnant human myometrium.Eur J Obstet Gynecol Reprod Biol.19(3):151-158 (1985).
Harlow et al, Antibodies a Laboratory Manual, Cold Spring Harbor Laboratories, 1989, Chap. 8, pp. 283-318.
Satoh et al., Role of prostaglandins in pregnancy-induced hypertension,Am. J. Kidney, 17(2):133-138 (1991).
Gryglewski et al., Prostacyclin and Vascular Disease,Philos. Trans. R. Soc. Lond. B. Biol. Sci., 294(1072):383-388 (1981).
Pereira et al., Molecular Cloning and Characterization of Bovine Prostacyclin Synthase,Biochem. Biophys. Res. Commun.203(1):59-65 (1994).

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