Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-22
2006-08-22
Winkler, Ulrike (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S388100, C530S389100
Reexamination Certificate
active
07094553
ABSTRACT:
The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPCand/or a denatured ungulate PrPSc, but not to a native ungulate PrPSc. Preferred antibodies find native bovine PrPCand treated PrPScbut not native bovine PrPScand can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
REFERENCES:
patent: 4806627 (1989-02-01), Wisniewski et al.
patent: 5792901 (1998-08-01), Prusiner et al.
patent: 5846533 (1998-12-01), Prusiner et al.
patent: 5891641 (1999-04-01), Prusiner et al.
patent: 5908969 (1999-06-01), Prusiner et al.
patent: 6261790 (2001-07-01), O'Rourke
patent: EP-0861900 (1998-09-01), None
patent: WO 99/42829 (1999-08-01), None
patent: WO 99/66956 (1999-12-01), None
patent: WO 01/05426 (2001-01-01), None
patent: WO 01/07479 (2001-02-01), None
Zanusso et al. Prion protein expression in different species: analysis with a panel of new antibodies. Proceedings of the National Academy of Science USA (1998) vol. 95, pp. 8812-8816.
Keulen et al. Immunohistochemical detection of prion protein in lymphoid tissue of sheep with natural scrapie. Journal of Clinical Microbiology (1996) vol. 34, No. 5, pp. 1228-1231.
Harmeyer et al. Synthetic peptide vaccines yield monoclonal antibodies to cellular pathological prion proteins of ruminants. Journal of General Virology (1998) vol. 79, pp. 937-945.
Meyer et al. Detection of bovine spongiform encephalopathy-specific PrPSc by treatment with heat and guanidine thiocyanate. Journal of Virology (1999) vol. 73, pp. 9386-9392.
Chapter 3 In: Antibodies: a laboratory manual. Ed. Harlow and Lane. Cold Spring Harbor Laboratory (1988) pp. 23-35.
Williamson et al. Mapping the prion protein using recombinant antibodies. Journal of Virology (1998) pp. 9413-9418.
Safar et al., “Eight prion strains have PrPScMolecules with different conformations,” Nature Medicine, Nature Publishing Co., 4(10):1157-1165 (Oct. 1998).
Peretz et al., “A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform,” Journal of Molecular Biology 273(3):614-622 (Oct. 1997).
Prusiner et al., “Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy” Journal of Infectious Diseases, Chicago, IL, US 167:602-613 (Mar. 1, 1993).
Prusiner et al., “Genetics of Prions” Annual Review of Genetics, Annual Reviews Inc. Palo Alto, CA, US 31:139-175 (1997).
Grathwohl et al. (1997), “Sensitive Enzyme-Linked Immunosorbent Assay for Detection of PrPSc in Crude Tissue Extracts from Scrapie-Affected Mice.”Journal of Virological Methods, vol. 64:205-216.
Rogers et al. (Apr. 1993), “Conversion of Truncated and Elongated Prion Proteins into the Scrapie Isoform in Cultured Cells.”Proc. Natl. Acad. Sci. USA, vol. 90:3182-3186.
Scott et al. (Dec. 21, 1999), “Compelling Transgenic Evidence for Transmission of Bovine Spongiform Encephalopathy Prions to Humans.”PNAS, vol. 96(26): 15137-15142.
Serban et al. (Jan. 1990), “Rapid Detection of Creutzfeldt-Jakob Disease and Scrapie Prion Proteins.”Neurology, vol. 40:110-116.
Taraboulos et al. (Aug. 1992), “Regional Mapping of Prion Proteins in the Brain.”Proc. Natl. Acad. Sci. USA, vol. 89:7620-7624.
Tollin et al. (Jun. 1986), “Redox Pathways in Electron/Transfer Proteins: Correlations Between Reactivities, Solvent Exposure, and Unpaired-Spin-Density Distributions.”Proc. Natl. Acad. Sci. USA, vol. 83:3693-3697.
Burton Dennis R.
Prusiner Stanley B.
Safar Jiri G.
Williamson R. Anthony
Bozicevic Karl
Bozicevic Field & Francis LLP
The Regents of the University of California
The Scripps Research Institute
Winkler Ulrike
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