Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-09-28
2000-10-17
Eyler, Yvonne
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 721, 435 71, 435975, 435960, 5303879, 5303877, 53038885, 5303888, 5303897, G01N 33574, C07K 1630
Patent
active
061329800
ABSTRACT:
The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention relates to the identification of a second tumor antigen recognized by a HLA-A31 restricted CTL clone derived from the TIL586 cell line. This antigen derived from the TRP-2 protein tumor antigen and peptides thereof are capable of sensitizing target cells for lysis by a CTL clone at 1 nM peptide concentration. Modified peptides were also recognized by the CTL clone.
REFERENCES:
Pavan, W.J. et al. Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. Proc. Natl. Acad. Sci., USA, 91: 7159-7163, Jul. 1993.
Abdel-Malek, Z. et al. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc. Natl. Acad. Sci., USA, 92: 1789-1793, Feb. 1995.
Pastorek, J. et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene, 9: 2877-2888, 1994.
Brichard, et al., "The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T. Lymphocytes on HLA-A2 Melanomas", J. Exp. Med., 1993, 178:489-495.
Robbins, et al., "Recognition of Tyrosinase by Tumor-infiltrating Lymphocytes from a Patient responding to Immunotherapy", Cancer Res., 1994, 54:3124-3126.
Wang et al., "Identification of a Gene Encoding a Melanoma Tumor Antigen Recognized by HLA-A31-restricted Tumor-infiltrating Lymphocytes", J. Exp. Med., 1995, 181:799-804.
Topalian, et al., "Melanoma-specific CD4' T Cells Recognized Nonmutated HLA-DRA-restricted Tyrosinase Epitopes", J. Exp. Med., 1996, 183:1965-1971.
Schadendorf et al., "Metastatic potential of human melanoma cells in nude mice--characteristics of phenotype, cytokine secretion and tumour-associated antigen", Brit. J. Cancer, 1996, 74:194-199.
Houghton, "Cancer Antigens Immune Recognition of Self and Altered Self", J. Exp. Med., 1994, 180:1-4.
Kawakami, et al., "Human Melanoma Antigens Recognized by T. Lymphocytes", Keio J. Med., Jun. 1996 45(2):100-108.
Yokoyama, et al., "Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2" Biochim. Biophys. Acta, 1994, 1217:317-321.
Bouchard, et al., "Molecular characterization of a human tyrosinase-related protein-2 cDNA" Eur. J. Biochem., 1994, 219:127-134.
Bouchard, et al., "Production and Characterization of Antibodies Against Human Tyrosinase", The Journal for Investigative Dermatology, 1994, 102:291-295.
Cassady, et al., "Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA" Gene, 1994, 143;295-298.
Tsukamoto, K. et al., "A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase" The EMBO Journal, 1992, 11:519-529.
Rosenberg Steven A.
Wang Rong Fu
Eyler Yvonne
Holleran Anne L.
The United States of America as represented by the Department of
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