Antibodies specific for platelet-activating factor acetylhydrola

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303871, 435 71, 435 72, 435 79, 435 7021, 435326, 435327, 435328, 435331, 435338, 4352872, 435174, 43524027, 422 88, 436548, 436500, 514 2, C07K 1528, C12N 512, C12N 900, G01N 3353

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active

058470883

ABSTRACT:
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.

REFERENCES:
patent: 5019508 (1991-05-01), Johnson et al.
patent: 5279957 (1994-01-01), Gross
patent: 5530101 (1996-06-01), Queen et al.
Stremler et al. JBC 264:5331-5334, 1989.
Roitt et al, In Immunology Gower Medical Publishing Co. p. 25.7, 1985.
Adjei and Garren, "Pulmonary Delivery of Peptide Drugs: Effects of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers", Pharm. Res., 7(6):565-569 (1990).
Basran, "Properties of Platelet Activating Factor (PAF-ACETHER) Which Suggest Involvement in Chronic Inflammation and Persistent Asthma", Br. J. Pharmacol., 77:437 (1982).
Braquet et al., Effect of Endothelin-1 on Blood Pressure and Bronchopulmonary System of the Guinea Pig, J. Cardio. Pharm., 13 (Supp. 5):S143-S146 (1989).
Brenner, "The molecular evolution of genes and proteins: a tale of two serines", Nature, 334:528-530 (Aug. 11, 1988).
Capecchi, "Altering the Genome by Homologous Recombination", Science, 244:1288-1292 (Jun. 16, 1989).
Caplan et al., "Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis", J. Pediatr., 116(6):960-964 (June. 1990).
Chapus et al., "Minireview of pancreatic lipase and colipase", Biochimie, 70:1223-1224 (1988).
deBoer et al., "The tac promoter: A functional hybrid derived from the trp and lac promoters", Proc. Natl. Acad. Sci. USA, 80:21-25 (Jan. 1983).
Debs et al., "Lung-Specific Delivery of Cytokines Induces Sustained Pulmonary and Systemic Immunomodulation in Rats", J. Immunol., 140(10):3462-3488 (May 15, 1933).
Denizot et al., "PAF-Acether and Acetylhydrolase in Stool of Patients with Crohn's Disease", Digestive Diseases and Sciences, 37(3):432-437 (Mar. 1992).
Furukawa et al., "Platelet-Activating Factor-Induced Ischemic Bowel Necrosis: The Effect of Platelet-Activating Factor Acetylhydrolase", Ped. Res., 34(2):237-241 (1993).
Grino et al., "BN 52021: A Platelet Activating Factor Anatagonist for Preventing Post-Transplant Renal Failure", Anna Int. Med., 121(5):345-347 (Sep. 1, 1994).
Hahn et al., "The complete sequences of plasmids, pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines", Gene, 127:267-268 (1993).
Handley and Saunders, "Platelet Activating Factor and Inflammation in Atherogenesis: Targets for Drug Development", Drug. Dev. Res., 7:361-375 (1986).
Hattori et al., "Purification and Characterization of Bovine Brain Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 268(25):18748-18753 (Sep. 5, 1993).
Hattori et al., "The Catalytic Subunit of Bovine Brain Platelet-activating Factor Acetylhydrolase Is a Novel Type of Serine Esterase", J. Biol. Chem., 269(37):23150-23155 (Sep. 16, 1994).
Henriques et al., "Endothelin-1 inhibits PAF-induced paw oedema and pleurisy in the mouse", Br. J. Pharmacol., 106:579-582 (1992).
Heuer, "Current status of PAF Antagonists", Clin. Exp. allergy, 22:980-983 (1992).
Hoffman et al., "Detection of platelet-activating factor in amniotic fluid of complicated pregnancies", Am. J. Ostet. Gynecol., 162(2):525-528 (1990).
Hubbard et al., "Anti-Neutrophil-Elastase Defenses of the Lower Respiratory Tract in .alpha.1-Antitrypsin Deficiency Directly Augmented with an Aerosol of A1-Antitrypsin", Annals of Internal Medicine, III(3):206-212 (Aug. 1, 1989).
Hsieh and Ng, "Increased plasma platelet-activating factor in children with acute asthmatic attacks and decreased in vivo and in vitro production of platelet-activating factor after immunotherapy", J. Allergy Clin. Immunol., 91:650-657 (Feb. 1993).
Hsueh et al., "Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis", Acta P.oe butted.diatr. Suppl. 396:11-17 (1994).
Hubbard et al., "Anti-Neutrophil-Elastase Defenses of theLower Respiratory Tract in .alpha.1-Antitrypsin Deficiency Directly Augmented with an Aerosol of A1-Antitrypsin", Annals of Internal Medicine, III(3):206-212 (Aug. 1, 1989).
Kald et al., "Release of Platelet-Activating Factor in Acute Experimental Pancreatitis", Pancreas, 8(4):440-442 (1993).
Kirsch et al., "Mechanism of Platelet Activating Factor-Induced Vascular Leakage in the Rat Trachea", Exp. Lung Res., 18:447-459 (1992).
Kurosawa et al., "Increased levels of blood platelet-activating factor in bronchial asthmatic patients with active symptoms", Allergy, 49:60-63 (1994).
LaVallie et al., "A Thioredoxin Gene Fusion Expression System That Circumvents Inclusion Body Formation in the E. coli Cytoplasm", Bio/Technology, 11:187-193 (Feb. 11, 1993).
Lellouch-Tubiana et al., "Eosinophil Recruitment into Guinea Pig Lungs after PAF-acether and Allergen Administration", Am. Rev. Respir. Dis., 137:948-954 (1988).
Lellouch-Tubiana et al., "Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) in guinea-pigs", Br. J. Exp Path., 66:345-355 (1985).
Lewin, pp. 136-141 in Genes V, Oxford University Press, New York, New York (1994).
Lindsberg et al., "Evidence for Platelet-Activating Factor as a Novel Mediator in Experimental Stroke in Rabbits", Stroke, 21(10):1452-1457 (Oct. 1990).
Lindsberg et al., "Platelet-activating Factor in Stroke and Brain Injury", Ann. Neurol., 30(2):117-129 (Aug. 1991).
Maki et al., "Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation", Proc. Natl. Acad. Sci. USA, 85:728-732 (Feb. 1988).
Matsumoto et al., "Platelet-Activating Factor in Bronchoalveolar Lavage Fluid of Patients With Adult Respiratory Distress Syndrome", Clin. Exp. Pharmacol. Physiol., 19:509-515 (1992).
Matsuzaki et al., "PAF acetylhydrolase activities in human systemic lupus erythematosus and lupus-prone mice", Clinica Chimica Acta, 210:139-144 (1992).
Mezzano et al., "Detection of Platelet-Activating Factor in Plasma of Patients with Streptococcal Nephritis", J. Am. Soc. Nephrol., 4:235-242 (1993).
Miwa et al., "Characterization of Serum Platelet-activating Factor (PAF) Acetylhydrolase", J. Clin. Invest., 82:1983-1991 (Dec. 1988).
Rabinovici et al., "ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rate", J. Appl. Physiol., 74(4):1791-1802 (1993).
Rabinovici et al., "Platelet Activating Factor Mediates Interleukin-2-induced Lung Injury in the Rat", J. Clin. Invest., 89:1669-1673 (May 1992).
Rodrigeuz-Roisin et al., "Platelet-activating Factor Causes Ventilation-Perfusion Mismatch in Humans", J. Clin. Invest., 93:188-194 (Jan. 1994).
Sandhu et al., "Amplification of Reproducible Allele Markers for Amplified Fragment Length Polymorphism Analysis", Biotechniques, 12(1):14-16 (1992).
Satoh et al., "Platelet-activating Factor (PAF) Stimulates the Production of PAF Acetylhydrolase by the Human Hepatoma Cell Line, HepG2", J. Clin. Invest., 87:476-481 (Feb. 1991).
Satoh et al., Platelet-Activating Factor Acetylhydrolase in Plasma Lipoproteins From Patients With Ischemic Stroke, Stroke, 23:1090-1092 (1992).
Smith et al., "Pulmonary Deposition and Clearance of Aerosolized Alpha-1-Proteinase Inhibitor Administered to Dogs and to Sheep", J. Clin. Invest., 84:1145-1154 (Oct. 1989).
Stafforini et al., "Human Macrophages Secrete Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 265(17):9682-9687 (Jun. 15, 1990).
Stafforini et al., "Human Plasma Platelet-activating Factor Acetylhdrolase: Association with lipoprotein particles and role in the degradation of platelet-activating factor", J. Biol. Chem., 262(9):4215-4222 (Mar. 25, 1987).
Stafforini et al., "Human Plasma Platelet-activating Factor Acetylhydrolase: Purification and Properties", J. Biol. Chem., 262(9):4223-4230 (Mar. 5, 1987).
Stafforini et al., "Lipoproteins alter the catalytic be

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