Antibodies specific for phosphorylation sites and screening...

Details Antibodies specific for phosphorylation sites and screening... Antibodies specific for phosphorylation sites and screening...

2004-04-13

2008-08-26

Canella, Karen A. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387700, C530S387900, C530S389100, C530S389200, C530S389700, C530S300000, C530S326000, C530S327000, C435S007100

Reexamination Certificate

active

07417124

ABSTRACT:
Polyclonal antibody specific for a phosphorylated linker region in Smad2 and/or Smad3.

REFERENCES:
patent: 6103869 (2000-08-01), Souchelnytokyi et al.
Furukawa et al. (Hepatology, Sep. 27, 2003, 38:879-889).
Harlow and Lane (Antibodies, a Laboratory Manual, Cold Spring Harbor Laboratory Press, 1988, p. 93-94 and p. 142).
Kretzschmar et al., “A Mechanism of Repression of TGFβ/Smad Signaling by Oncogenic Ras”, Genes & Development 13:804-816 (1999), discussed in the specification.
Kretzschmar et al., Nature 389:618-622 (1997), discussed in the specification.
Heldin et al., Nature 390:465-471 (1997), discussed in the specification.
Lindemann et al; “Interfering with TGFβ-induced Smad3 nuclear accumulation differentially affects TGFβ-dependent gene expression”; Molecular Cancer 2003; 2:20; pp. 1-10.
Wang et al; “Requirement of Mitogen-activated Protein Kinase Kinase 3 . . . in Murine Mesangial Cells*”; J. Biological Chemistry; 2002; 277:49 pp. 47257-47262.
Leioven et al; “Smad3 Mediates Transforming Growth Factor-β-induced Colagenase-3 . . . Fibroblasts” J. Biological Chemistry; 2002; 277:48; pp. 46338-45346.
Bakin et al; “p38 mitogen-activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration;” J. Cell Science 2002; 115, pp. 3192-3206.
Tahashi et al; “Differential Regulation of TGF-β Signal in . . . Rat Liver Injury;” American Association for Liver Studies; 2002; pp. 49-61.
Matsuzaki et al; “Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury;” GUT, May 2000; 46:3; pp. 719-724.
Matsuzaki et al; “Regulatory Mechanisms for Transforming Growth Factor β as an Autocrine Inhibitor . . . in its Growth;” American Association for Liver Studies 2000; pp. 218-227.
Matsuzaki et al; “Autocrine Stimulatory Mechanism by Transforming Growth Factor β in Human Hepatocellular Carcinoma”; Cancer Research 60; Mar. 1, 2000; pp. 1394-1402.
Ravanti et al; “Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor-β via p38 mitogen-activated protein kinase;” FASEB J. 10-1096; published online Feb. 20, 2001.
Moustakas et al; “Smad regulation in TGF-β signal transduction”; J. Cell Science 2001; 113; pp. 4359-4369.
Date et al; “Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CCl4administration”; J. Hepatology 1998; 28: pp. 572-581.
Heldin et al; “TGF-β signalling from cell membrane to nucleus through SMAD proteins.” Nature (Dec. 1997); 390:4; pp. 465-471.(see spec. p. 2).
Kretzschmar et al; “Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad-1;” Nature (Oct. 1997) 389:9; pp. 618-622.

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