Antibodies specific for oncofetal fibronectin

Details Antibodies specific for oncofetal fibronectin Antibodies specific for oncofetal fibronectin

1994-03-22

1996-06-04

Feisse, Lila

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 72, 53038825, 5303871, 5303881, 530380, C12N 512, C07K 1618, C07K 1478, G01N 3353

Patent

active

055232299

ABSTRACT:
Immunologic binding partners which specifically bind to oncofetal fibronectin but not normal adult fibronectin or blood plasma fibronectin and methods of diagnosing and treating oncogenesis and reproductive abnormalities employing the same.

REFERENCES:
patent: 4894326 (1990-01-01), Matsuura et al.
Matsuura et al., "The Oncofetal Structure of Human Fibronectin Defined by Monoclonal Antibody FDC-6", J. Biol. Chem. 263: 3314-3322 (1988).
Matsuura et al., "An .alpha.-N-Acetylgalactosaminylation at the Threonine Residue of a Defined Peptide Sequence Creates the Oncofetal Peptide Epitope in Human Fibronectin", J. Biol. Chem. 264: 10472-10476 (1989).
Matsuura and Hakomori, "The Oncofetal Domain of Fibronectin Defined by Monoclonal Antibody FDC-6: Its Presence in Fibronectins from Fetal and Tumor Tissues and Its Absence in those from Normal Adult Tissues and Plasma", Proc. Natl. Acad. Sci. USA 82: 6517-6521 (1985).
Mandel, V. et al, APMIS, 100(9):817-826, 1992.
Loridon-Rosa, B. et al., Cancer Res., 50(5):1608-1612, 1990.

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