Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1998-11-03
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038824, 5303892, 530397, C07K 1622, C12P 2108
Patent
active
058310304
ABSTRACT:
The present invention provides novel megakaryocyte differentiation factors, which are useful as therapeutic agents due to their accelerating effects on the differentiation of megakaryocytes and their thrombopoietic effects. The megakaryocyte differentiation factors of the present invention include the megakaryocyte differentiation factor having the amino acid sequence shown in SEQ ID NO: 34. The present invention also provides DNA coding for the megakaryocyte differentiation factors of the present invention, expression vectors containing the DNA, hosts transformed with the expression vectors, and processes for production of the megakaryocyte differentiation factors using transformed hosts. The present invention further provides specific antibodies to the megakaryocyte differentiation factors of the present invention.
REFERENCES:
Cunningham, B. A. et al. Science 236: 799-806, May 15, 1987.
Chemical Abstracts 113: 22039y, vol. 113, 1990.
H. Mizoguchi: Tanpakushitsu Kakusan Koso, 36, 1195-1201, 1991.
I. Matsuda et al.: Tanpakushitsu Kakusan Koso, 36, 1184-1194, 1991.
N. Yamaguchi et al.: "Characterization of New Human Pancreatic Cancer Cell Lines Which Propagate in a Protein-free Chemically Defined Medium," Cancer Res., 50, 7008-7014, 1990.
Ishida Nobuhiro
Iwasa Fuyuki
Kurihara Tatsuya
Miura Kenju
Nakazato Hiroshi
Eisenschenk Frank C.
Rabin Evelyn
Suntory Limited
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