Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-01-07
1996-01-16
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303871, 5303881, 5303877, 53038826, 5303888, C12Q 125, C07K 1640, C07K 1630
Patent
active
054847265
ABSTRACT:
The present invention relates to a gene encoding stromylsin-3, which is a new member of the metalloproteinase family. Expression of the stromelysin-3 gene has been found to be specifically associated with invasive breast, head, neck and skin cancer. The invention also relates to antibodies which specifically bind to human stromylsin-3 and the use of these stromelysin-3 antibodies for detection of the stromylsin-3 protein in a sample.
REFERENCES:
Poupon, M. F. et al. (1991) Bulletin Du Cancer 78: 767-768.
Majmudar et al. (1992) Journal of Investigative Dermatology 98: 572, Abstract 121.
Hahnel et al. (1993) Journal of Cancer 55: 771-774.
Urbanski et al. (1992) British J. Cancer 66: 1188-1194.
Ahmed, Ali, "The Myofibroblast in Breast Disease", Pathol. Annu. 25(Pt 2): 237-286 (1990).
Basset, Paul et al., "Expression of the Stromelysin-3 Gene in Fibroblastic Cells of Invasive Carcinomas of the Breast and Other Human Tissues: A Review", Breast Cancer Research and Treatment 24:185-193 (1993).
Basset, Paul et al., "A Novel Metalloproteinase Gene Specifically Expressed in Stromal Cells of Breast Carcinomas", Nature 348:699-704 (Dec. 20, 1990).
Blood, Christine H. et al., "Tumor Interactions with the Vasculature: Angiogenesis and Tumor Metastasis", Biochim. et Biophys. Acta 1032:89-118 (1990).
Chiquet-Ehrismann, Ruth et al., "Tenascin: an Extracellular Matrix Protein Involved in Tissue Interactions during Fetal Development and Oncogenesis", Cell 47:131-139 (Oct. 10, 1986).
DeOme, K. B. et al., "Detection of Inapparent Nodule-transformed Cells in the Mammary Gland Tissues of Virgin Female BALB/cfC3H Mice", Cancer Research 38:2103-2111 (Jul. 1978).
Fidler, Isaiah J., "Origin and Biology of Cancer Metastasis", Cytometry 10:673-680 (1989).
Fidler, Isaiah J., "Rationale and Methods for the Use of Nude Mice to Study the Biology and Therapy of Human Cancer Metastasis", Cancer and Metastasis Reviews 5:29-49 (1986).
Garcia, M. et al., "Immunohistochemical Distribution of the 52-kDa Protein in Mammary Tumors: A Marker Associated with Cell Proliferation Rather Than With Hormone Responsiveness", J. Steroid Biochem. 27(1-3):439-445.
Goldberg, Gregory I. et al., "Human Fibroblast Collagenase-Complete Primary Structure and Homology to an Oncogene Transformation-Induced Rat Protein", J. Biol. Chem. 261(14):6600-6605 (May 15, 1986).
Grey, Anne-Marie et al., "Purification of the Migration Stimulating Factor Produced by Fetal and Breast Cancer Patient Fibroblasts", PNAS USA 86:2438-2442 (Apr. 1989).
Gullick, W. J., "Growth Factors and Oncogenes in Breast Cancer", Progress in Growth Factor Research 2:1-13 (1990).
Hart, Ian R. et al., "Molecular Aspects of the Metastatic Cascade", Biochim. et Biophys. Acta 989:65-84 (1989).
Kerr, Lawrence D. et al., "Growth Factors Regulate Transin Gene Expression By c-fos-Dependent and c-fos-Independent Pathways", Science 242:1424-1427 (Dec. 9, 1988).
Lefebvre, Olivier et al., "The Breast Cancer-Associated Stromelysin-3 Gene is Expressed During Mouse Mammary Gland Apoptosis", J. Cell Biology 119(4):997-1002 (Nov. 1992).
Levy, Annie et al., "Assignment of the Human Stromelysin 3 (STMY3) Gene to the q11.2 Region of Chromosome 22", Genomics 13:881-883 (1992).
Liotta, Lance A., "Tumor Invasion and Metastases-Role of the Extracellular Matrix: Rhoads Memorial Award Lecture", Cancer Research 46:1-7 (Jan. 1986).
Lippman, Marc E. et al., "Mechanisms of Growth Control in Normal and Malignant Breast Epithellium", Recent Progress in Hormone Research 45:383-440 (1989).
Matrisian, Lynn M., "Metalloproteinases and Their Inhibitors in Matrix Remodeling", Trends in Genetics 6(4):121-125 (Apr. 1990).
Milaire, J., "Aspects of Limb Morphogenesis", in Organogenesis (R. L. De Haan and H. Ursprung, eds.), Holt, Rinehart and Winston, New York, pp. 283-300 (1965).
Monteagudo, Carlos et al., "Immunohistochemical Distribution of Type IV Collagenase in Normal, Benign, and Malignant Breast Tissue", Am. J. Path. 136(3):585-592 (Mar. 1990).
Muller, Daniele et al., "The Collagenase Gene Family in Humans Consists of at Least Four Members", Biochem. J. 253:187-192 (1988).
Muller, Daniele et al., "Expression of Collagenase-Related Metalloproteinase Genes in Human Lung or Head and Neck Tumours", Int. J. Cancer 48:550-556 (1991).
Muller, Daniele et al., "Increased Stromelysin 3 Gene Expression Is Associated with Increased Local Invasiveness in Head and Neck Squamous Cell Carcinomas", Cancer Research 53:165-169 (Jan. 1, 1993).
Murphy, George J. P. et al., "The Origin of Matrix Metalloproteinases and Their Familial Relationships", FEBS 289(1):4-7 (Sep. 1991).
Nowell, Peter C., "Mechanisms of Tumor Progression", Cancer Research 46:2203-2207 (May 1986).
Polette, Myriam et al., "Detection of mRNAs Encoding Collagenase I and Stromelysin 2 in Carcinomas of the Head and Neck by in situ Hybridization", Invasion Metastasis 11:76-83 (1991).
Salomon, David S. et al., "Tumor-Associated Growth Factors in Malignant Rodent and Human Mammary Epithelial Cells", in Breast Cancer: Cellular and Molecular Biology (M. E. Lippman and R. B. Dickson, eds.), Kluwer Academic Publishers, Boston, pp. 363-389 (1988).
Tremblay, Gilles, "Stromal Aspects of Breast Carcinoma", Experimental and Molecular Pathology 31:248-260 (1979).
Weinberg, Robert A., "Oncogenes, Antioncogenes, and the Molecular Bases of Multistep Carcinogenesis", Cancer Research 49:3713-3721 (Jul. 15, 1989).
Whitham, Sarah E. et al., "Comparison of Human Stromelysin and Collagenase by Cloning and Sequence Analysis", Biochem. J. 240:913-916 (1986).
Willett, Walter, "The Search for the Causes of Breast and Colon Cancer", Nature 338:389-394 (Mar. 30, 1989).
Wolf, Catherine et al., "Breast-Cancer-Associated Stromelysin-3 Gene Is Expressed in Basal Cell Carcinoma and During Cutaneous Wound Healing", J. Invest. Dermatol. 99:870-872 (Dec. 1992).
Basset Paul
Bellocq Jean-Pierre
Chambon Pierre
Arthur Lisa
Bristol--Myers Squibb Company
Centre National de la Recherche Scientifique
Institute National de la Sante et de la Recherche Medicale
Parr Margaret
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