Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1996-08-05
1999-12-21
Saunders, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 53038822, 53038875, 5303896, C07K 1628
Patent
active
060050802
ABSTRACT:
The present invention relates to a novel member of the hematopoietin receptor family, herein referred to as Hu-B1.219. In particular, the invention relates to nucleotide sequences and expression vectors encoding Hu-B1.219 gene product. Genetically engineered host cells that express the Hu-B1.219 coding sequence may be used to evaluate and screen for ligands or drugs involved in Hu-B1.219 interaction and regulation. Since Hu-B1.219 expression has been detected in certain human fetal tissues and cancer cells, molecular probes designed from its nucleotide sequence may be useful for prenatal testing and cancer diagnosis.
REFERENCES:
Miyajima et al., "Receptors For Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3, and Interleukin-5", Blood 82(7):1960-1974 (1993).
Miyajima et al., "Cytokine Receptors And Signal Transduction", Annu. Rev. Immunol. 19:295-331 (1992).
Park et al., "Cloning Of The Low-Affinity Murine Granulocyte-Marcophage Colony-Stimulating Factor Receptor And Reconstitution Of A High-Affinity Receptor Complex", PNAS U.S.A. 89:4295-4299 (1992).
Saito et al., "Molecular Cloning Of A Murine IL-6 Receptor-Associated Signal Transducer, gp130, And Its Regulated Expression In Vivo", J. Immunol. 148:4066-4071 (1992).
Bazan, "Structural Design And Molecular Evolution Of A Cytokine Receptor Superfamily", PNAS U.S.A. 87:6934-6938 (1990).
Cosman et al., "A New Cytokine Receptor Superfamily", TIBS pp. 265-269 (Jul. 1990).
Fukunaga et al., "Expression Cloning Of A Receptor For Murine Granulocyte Colony-Stimulating Factor", Cell 61:341-350 (1990).
Gorman et al., "Cloning and Expression Of A Gene Encoding An Interleukin 3 Receptor-Like Protein: Identification Of Another Member Of The Cytokine Receptor Gene Family", PNAS U.S.A. 87:5459-5463 (1990).
Harada et al., "Expression Cloning Of A cDNA Encoding The Murine Interleukin 4 Receptor Based On Ligand Binding", PNAS U.S.A. 87:857-861 (1990).
Hayashida et al., "Molecular Cloning Of A Second Subunit Of The Receptor For Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF): Reconstitution Of A High Affinity GM-CSF Receptor", PNAS U.S.A. 87:9655-9659 (1990).
Hibi et al., "Molecular Cloning And Expression Of An IL-6 Signal Transducer, gp130", Cell 63:1149-1157 (1990).
Larsen et al., "Expression Cloning Of A Human Granulocyte Colony-Stimulating Factor Receptor: A Structural Mosaic Of Hematopoietin Receptor, Immunoglobulin, And Fibronectin Domains", J. Exp. Med. 172:1559-1570 (1990).
Gearing et al., "Expression Cloning Of A Receptor For Human Granulocyte-Macrophage Colony-Stimulating Factor", EMBO J. 8:3667-7676 (1989).
Mosely et al., "The Murine Interleukin-4 Receptor: Molecular Cloning And Characterization Of Secreted And Membrane Bound Forms", Cell 59:335-348 (1989).
Yamasaki et al., "Cloning And Expression Of The Human Interleukin-6 (BSF-2/IFN.beta. 2) Receptor", Science 241:825-828 (1988).
Gearing et al., "Molecular Cloning And Expression Of cDNA Encoding A Murine Myeloid Leukaemia Inhibitory Factor (LIF)", EMBO J. 6:3995-4002 (1987).
Ono et al., "A Novel Human Nonviral Retroposon Derived From An Endogenous Retrovirus", Nuc. Acid. Res. 15:8725-8737 (1987).
Singer, "SINEs And LINEs: Highly Repeated Short And Long Interspersed Sequences In Mammalian Genomes", Cell 28:433-434 (1982).
Streamson et al., 1996, "Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor," Science 271:994-996.
Cioffi et al., 1996, "Novel B219/OB Receptor Isoforms: Possible Roles of Leptin in Hematopoiesis and Reproduction," Nature Medicine 2(5):585-589.
Beckmann et al., 1994, "Molecular Characterization of a Family of Ligands for eph-Related Tyrosine Kinase Receptors," EMBO Journal 13(16):3757-3762.
Tartaglia et al., 1995, "Identification and Expression Cloning of a Leptin Receptor, OB-R," Cell 83:1263-1271.
Dusanter-Fourt et al., 1994, "Transduction du Signal Par Les Recepteurs De Cytokines," Medecine Sciences 10:825-835.
Truett et al., 1991, "Rat Obesity Gene fatty (fa) Mapps to Chromosome 5: Evidence for Homology with the Mouse Gene diabetes (db)," Proc. Natl. Acad. Sci. U.S.A. 88:7806-7809.
Bahary et al., 1990, "Molecular Mapping of the Mouse db Mutation," Proc. Natl. Acad. Sci. U.S.A. 87:8642-8646.
Lai, KN et al. APMIS. 99: 434-442, 1991.
Taga, T et al. Proc. Nat. Acad. Sci. USA. 89: 10998-11001, Nov. 1992.
Zhang, XG et al. J. Exp. Med. 77: 1337-1342, Apr. 1994.
Cheng, L et al. Development. 120: 3145-3153, Nov. 1994.
Cosman, D et al. TIBS. 15: 265-270, Jul. 1990.
Harlow, E and Lane, DP. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. pp. 23-26, 72-77, 92-97, 128-135, 141-157, 1988.
Harlow, E and Lane, DP. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. pp. 613-633, 1988.
Cioffi Joseph
Shafer Alan Wayne
Snodgrass H. Ralph
Zupancic Thomas Joel
Progenitor, Inc.
Saunders David
Vander Vegt F. Pierre
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