Antibodies specific for E-selectin and the uses thereof

Details Antibodies specific for E-selectin and the uses thereof Antibodies specific for E-selectin and the uses thereof

1994-12-29

1997-05-27

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241431, 4241721, 530395, 5303917, A61K 39395, A61K 3944, C07K 1628

Patent

active

056329911

ABSTRACT:
A method is provided for selectively targeting a therapeutic agent to a site of activated endothelium by administering a pharmaceutical composition comprising a therapeutically effective amount of an E-selectin (formerly called ELAM-1) specific monoclonal antibody conjugated to a therapeutic agent. An immunoconjugate comprising an E-selectin specific monoclonal antibody and a therapeutic agent is also provided. A method is also provided for the treatment of a vascular smooth muscle cell proliferative disorder, vasculitis, inflammation, post-reperfusion injury, microbial infections, acute or chronic allograft rejection, and leukemia, as well as for the inhibition of metastatic spread of tumor cells, by administering a pharmaceutical composition comprising a therapeutically effective amount of an E-selectin antibody, or antibody fragment, either alone, or conjugated to a therapeutic agent.

REFERENCES:
patent: 4675382 (1987-06-01), Murphy
patent: 4727028 (1988-02-01), Santerre et al.
patent: 4740470 (1988-04-01), Cohen et al.
patent: 4797277 (1989-01-01), Arfors
patent: 4840793 (1989-06-01), Todd, III et al.
patent: 5011778 (1991-04-01), Newman et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5116613 (1992-05-01), Haber et al.
patent: 5256413 (1993-10-01), Haber et al.
patent: 5403713 (1995-04-01), Bevilacqua et al.
Aruffo, A. and Seed, B., "Molecular cloning of a CD28 cDNA by a high efficiency COS cell expression system," PNAS USA 84:8573-8577 (1987).
Baggiolini et al., "Neutrophil-activating Peptide-1/Interleukin 8, a Novel Cytokine That Activates Neutrophils," J. Clin. Invest. 84:1045-1049 (1989).
Bar-Shavit et al., "Monocyte Chemotaxis: Stimulation by Specific Exosite Region in Thrombin," Science 220:278-731 (1983).
Benjamin et al., "A Blocking Monoclonal Antibody to Endothelial-Leukocyte Adhesion Molecule-1 (ELAM1)," Biochem. Biophys. Res. Comm. 171(1):348-353 (1990).
Bevilacqua, M.P. and Gimbrone, M.A., "Inducible Endothelial Functions in Inflammation and Coagulation," Seminars in Thrombosis and Hemostasis 13(4):425-433 (1987).
Bevilacqua, M.P. and Nelson, R.M., "Selectins," J. Clin. Invest. 91:379-387 (1993).
Bevilacqua et al., "Endothelial-Dependent Mechanisms of Leukocyte Adhesion: Regulation by Interleukin-1 and Tumor Necrosis Factor," Leukocyte Immigration and Its Sequelae, Satellite Symp. of the 6th Intl. Cong. of Immunol., Henry Z. Movat, ed., S. Karger, Basel, pp. 79-93 (1987).
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science 243:1160-1165 (1989).
Bevilacqua et al., "Endothelial-Leukocyte Adhesion: Stimulation of Endothelial Dependent Mechanisms by Monokines," 4th Intl. Symp. Biol. Vasc. Endothelial Cell:13 Abstract (1986).
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule," PNAS USA 84;9238-9242 (1987).
Bevilacqua et al., "Identification of an Inducible Endothelial-Leukocyte Adhesion Molecule (E-LAM 1) Using Monoclonal Antibodies (Mab)," Fed. Proc. 46:405 Abstract No. 514 (1987).
Bevilacqua et al., "Interleukin 1 Acts on cultured Human Vascular Endothelium to Increase the Adhesion of Polymorphonuclear Leukocytes, Monocytes, and Related Leukocyte Cell Lines," J. Clin. Invest. 76:2003-2011 (1985).
Bevilacqua et al., "Interleukin 1 (IL-1) Induces Biosynthesis and Cell Surface Expression of Procoagulant Activity in Human Vascular Endothelial Cells," J. Exp. Med. 160:618-623 (1984).
Bevilacqua et al., "Interleukin-1 Activation of Vascular Endothelium," Am. J. Path. 121:392-403 (1985).
Bevilacqua et al., "Regulation of the Fibrinolytic System of Cultured Human Vascular Endothelium by Interleukin 1," J. Clin. Invest. 78:587-591 (1992).
Bevilacqua et al., "Selectins: A Family of Adhesion Receptors," Cell 67:233 (1991).
Bode et al., "Fibrin-Targeted Recombinant Hirudin Inhibits Fibrin Deposition on Experimental Clots More Efficiently Than Recombinant Hirudin," Circulation 90:1956-1963 (1994).
Briscoe et al., "Predictive Value of Inducible Endothelial Cell Adhesion Molecule Expression for Acute Rejection of Human Cardiac Allografts," Transplantation 59(2) :204-211 (1995).
Brockmeyer et al., "Distribution of Cell Adhesion Molecules (ICAM-1, VCAM-1, ELAM-1) in Renal Tissue During Allograft Rejection," Transplantation 55(3):610-615 (1993).
Cavender et al., "Interleukin 1 Increases the binding of Human B and T Lymphocytes to Endothelial Cell Monolayers," J. Immunol. 136(1):203-207 (1986).
Chang, P. and Aronson, D.L., "A Microtiter Plate Reader Assay for Factor VIII," Thrombosis Research 66:599-602 (1992).
Collins et al., "Structure and Chromosomal Location of the Gene for Endothelial-Leukocyte Adhesion Molecule 1," J.Biol. Chem. 266(4):2466-2473 (1991).
Collins et al., "Von Willebrand Factor Release and P-Selectin Expression is Stimulated by Thrombin and Trypsin but not IL-1 in Cultured Human Endothelial Cells," Thromb. Haemostasis 70(2):346-350 (1993).
Cotran et al., "Endothelial Activation During Interleukin 2 Immunotherapy," J. Immunol. 139(12):1883-1888 (1987).
Cotran et al., "Induction and Detection of a Human Endothelial Activation Antigen In Vivo," J. Exp. Med. 164:661-666 (1986).
Cybulsky, M.I. and Gimbrone, M.A., "Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis," Science 251:788-791 (1991).
Daniel et al., "Thrombin Stimulates c-sis Gene Expression in Microvascular Endothelial Cells," J.Biol. Chem. 261(21):9579-9582 (1986).
Darnell et al., in: Molecular Cell Biology, Scientific American Books, Inc., p. 662 (1986).
Davey, M.G. and Luscher, E.F., "Actions of Thrombin and Other Coagulent and Proteolytic Enzymes on Blood Platelets," Nature 216:857-858 (1967).
Dewerchin et al., "Effect of Chemical Conjugation of Recombinant Single-Chain Urukinase-Type Plasminogen Activator With Monoclonal Antiplatelet Antibodies on Platelet Aggregation and on Plasma Clot Lysis In Vitro and In Vivo," Blood 78(4):1005-1018 (1991).
Drake et al., "Expression of Tissue Factor, Thrombomodulin, and E-Selectin in Baboons with Lethal Escherichia coli Sepsis," Amer. J. Pathol. 142(5):1458-1470 (1993).
Dunn, C.J. and Fleming, W.E., "The Role of Interleukin-1 in the Inflammatory Response with Particular Reference to Endothelial Cell-Leukocyte Adhesion," in: The Physiologic, Metabolic and Immunologic Actions of Interleukin-1, Kluger et al., eds., Liss, N.Y., pp. 45-54 (1985).
Dustin et al., "Induction by IL 1 and Interferon-.gamma.: Tissue Distribution, Biochemistry, and Function of a Natural Adherence Molecule (ICAM01)," J. Immunol. 137(1):245-254 (1986).
Fuggle et al., "Variation in Expression of Endothelial Adhesion Molecules in Pretransplant and Transplanted Kidneys--Correlation with Intragraft Events," Transplantation 55(1) :117-123 (1993).
Gamble et al., "Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor," PNAS USA 82:8667-8671 (1985).
Garcia et al., "Thrombin-Induced Increase in Albumin Permeability Across the Endothelium," J. Cell. Physiol. 128:96-104 (1986).
Gimbrone, M.A., "Vascular Endothelium: Nature's Blood-Compatible Container," Ann. N.Y. Acad. Sci. 516:5-11 (1987).
Gimbrone et al., "Endothelial-dependent Mechanisms of Leukocyte Adhesion: Role of Monokines," Thromb. Hemostas. 58:325 Abstract No. 1184 (1987).
Graham, D.J. and Alexander, J.J, "The effects of thrombin on bovine aortic endothelial and smooth muscle cells," J. Vasc. Surg. 11:307-313 (1990).
Gundel et al., "Endothelial Leukocyte Adhesion Molecule-1 Mediates Antigen-induced Acute Airway Inflammation and Late-phase Airway Obstruction in Monkeys," J. Clin. Invest. 88:1407-1411 (1991).
Haber et al., "Innovative Approaches to Plasminogen Activator Therapy," Science 243:51-56 (1989).
Harker, L.A., "Strategies for inhibiting the effects of thrombin," Blood Coagulation and Fibrinolysis 5(1) :S47-S58 (1994).
Harlan, J.M., "Leukocyte-Endothelial Interactions," Blood 65(3):513-525 (1985).
Harlan et al., ".alpha.-Thrombin Induces Release of Platelet-derived Growth Fac

Affiliated with

Also associated with

Rating

Antibodies specific for E-selectin and the uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies specific for E-selectin and the uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies specific for E-selectin and the uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2327182