Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-05
1996-04-09
Budens, Robert D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303877, 5303879, 5303888, 5303897, 4241381, 4241551, 4241561, 435 7021, 4351722, 43524027, C07K 1618, A61K 39395, C12N 520
Patent
active
055063446
ABSTRACT:
The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.
REFERENCES:
Tsujimoto et al., "Analysis of the Structure, Transcripts, and Protein Products of bcl-2, the Gene Involved in Human Follicular Lymphoma", Proc. Natl. Acad. Sci. USA 83:5214-5218 (1986).
Tsujimoto et al., "The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining", Science, 229:1390-1393 (1985).
Tsujimoto et al., "DNA Rearrangements in Human Follicular Lymphoma can Involve the 5' or the 3' region of the bcl-2 Gene", Proc. Natl. Acad. Sci. USA 84:1329-1331 (1987).
Tsujimoto et al., "Clustering of Breakpoints on Chromosome II in Human B-Cell Noeplasms with the t(11;14) Chromosome Translocation", Nature 315:340-343 (1985).
Tsujimoto et al., "Involvement of the bcl-2 Gene in Human Follicular Lymphoma", Science 228:1440-1443 (1985).
Tsujimoto et al., "Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation", Science 226:1097-1099 (1984).
Pegoraro et al., "A 14;18 and an 8;14 Chromosome Translocation in a Cell Line Derived from an Acute B-Cell Leukemia", Proc. Natl. Acad. Sci. USA 81:7166-7170 (1984).
Cleary et al., "Nucleotide Sequence of a t(14;18) Chromosomal Breakpoint in Follicular Lymphoma and Demonstration of a Breakpoint-Cluster Region Near a Transcriptionally Active Locus on Chromosome 18", Proc. Natl. Acad. Sci. USA 82:7439-7443 (1985).
Ngan et al., New England Journal of Medicine 318:1638-1644 (1988).
Reed et al., Nature 336: 259-261 (1988).
Croce Carlo A.
Tsujimoto Yoshihide
Budens Robert D.
Reeves Julie E.
The Wistar Institute
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