Antibodies specific for a haemostatic protein their use for isol

Details Antibodies specific for a haemostatic protein their use for isol Antibodies specific for a haemostatic protein their use for isol

1997-02-10

1999-08-03

Huff, Sheela

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

5303893, 53038825, A61K 39395

Patent

active

059327065

ABSTRACT:
A method for the generation of Ca++ independent antibodies against blood coagulation factors is described wherein an antibody selection strategy based upon small peptides comprising target sequences for limited proteolysis is employed. These antibodies which distinguish between intact and cleaved species of haemostatic protein provide novel tools for the isolation of intact haemostatic proteins.

REFERENCES:
patent: 5252712 (1993-10-01), Furie et al.
patent: 5336610 (1994-08-01), Esmon et al.
Pelzer et al Thromb and Haemostasis vol. 65(2) 153-159, 1991.
New Riverside Dictionary p. 622. Webster's II Fifth Edition. Theodorsson et al. 1983 Blood: vol. 61 No. 5: 973-981.
Lerner 1982 Nature vol. 299: 592-596. Furie et al 1988 Cell vol. 53: 505-518.
Verlander et al 1989 Biotechnology Progress vol. 5 No. 3 119-125.

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