Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-10-20
1998-10-13
Loring, Susan A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435325, 435330, 5302871, 5303877, 5303888, 5303913, G01N 33574, G01N 3353, C07K 1630, C12N 512
Patent
active
058210709
ABSTRACT:
This invention provides novel antibodies specifically reactive with a nuclear retinoblastoma-associated polypeptide, wherein the polypeptide specifically binds to the protein product of the retinoblastoma gene. Also provided by this invention are antibodies specifically reactive with proteins having E2F biological activity. Methods of using these antibodies also are claimed.
REFERENCES:
patent: 4942123 (1990-07-01), Lee et al.
Char, DH et al., Retina, 3(3):200-5, 1983.
Sevier,ED et al, Clin. Chem., 27(11):1797-1806, 1981.
Ali et al., "Retinoblastoma Gene Product-Associated Proteins in Human Colan Cancer Cell Lines"; Biochem. and Biophys. Res. Comm. 194(2): 848-854 (1993).
Bandara et al., "Cyclin A and the Retinoblastoma Gene Product Complex with a Common Transcription Factor"; Nature 352: 249-251 (1991).
Helin et al., "A cDNA Encoding a pRB-Binding Protein with Properties of the Transcription Factor E2F"; Cell 70: 337-350 (1992).
Defeo-Jones et al., "Cloning of cDNA's for Celllular Proteins that Bind to the Retinoblastoma Gene Product"; Nature 352: 251-254 (1991).
Kaelin, Jr. et al., "Identification of Cellular Proteins tha can Interact Specifically with the T/E1A-Binding Region of the Retinblastoma Gene Product"; Cell 64: 521-532 (1991).
Kaelin, Jr. et al., "Expression Cloning of a cDNA Encoding a Retinblastoma-Binding Protein with E2F-like Properties"; Cell 70: 351-364 (1992).
Nevins, J.R., "E2F: A Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins"; Science 258: 427-428 (1992).
Ray et al., "Identification of a 60-Kilodalton Rb-Binding Protein, RBP60, That Allows the Rb-E2F Complex to Bind DNA"; Mol. and Cell. Biology 12(10): 4327-4333 (1992).
Huang, Shi et al., Nature, 350: 160-162, 14 Mar. 1991.
Sevier, E.D. et al, Clin. Chem, 27(11):1797-1806, 1981.
Defeo-Jones, et al, Nature, 352:251-254, 18 Jul. 1991.
Austin, C.A. et al, FEBS LETTERS, 266(1,2):115-117, Jun. 1990.
Fung et al., "Function of the Human Retinoblastome Gene" in Recessive Oncogenes and Tumor Suppression, Cavenee, Hastie and Stanbridge, Eds., Cold Spring Harbor Laboratory Press, New York, pp. 117-123 (1989).
Cooper, G.M., in Oncogenes, Jones and Bartlett Publishers, Boston, Mass., pp. 121-139 (1990).
Marx, J.L., "Eye Cancer Gene Linked to New Malignancies" Science 241:293-294 (1988).
Lee et al., "Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers" Science 241:218-221 (1988).
Yokota et al., "Altered expression of the retinoblastoma (RB) gene in small cell carcinoma of the lung" Oncogene 3:471-475 (1988).
Dryja et al., "Genetic Sequences That Predispose to Retinoblastoma and Osteosarcoma" Symposium on Fundamental Cancer Research by The University of Texas System Cancer Center, vol. 39, pp. 115-119 (1987).
Horowitz et al., "Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells" PNAS USA 87:2775-2779 (1990).
Fung et al., "Structural Evidence for the Authenticity of the Human Retinoblastoma Gene" Science 236:1657-1661 (1987).
Cavenee et al., "Expression of recessive alleles by chromosomal mechanisms in retinoblastoma" Nature 305:779-784 (1983).
Lalande et al., "Molecular Detection and Differentiation of Deletions in Band 13q14 in Human Retinoblastoma" Cancer Genet. Cytogenet. 23:151-157 (1986).
Lee et al., "Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence" Science 235:1394-1399 (1987).
Kolata, G., "Human Cancer Gene Sequenced" Science, p. 1323 (13 Mar. 1987).
DeCaprio et al., "SV40 Large Tumor Antigen Forms a Specific Complex with the Product of the Retinoblastoma Susceptibilty Gene" Cell 54:275-283 (1988).
Dyson et al., "The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product" Science 243:934-937 (1989).
Dryja et al., "Chromosome 13 Homozygosity in Osteosarcoma without Retinoblastoma" Am. J. Hum. Genet. 38:59-66 (1986).
Rapaport et al., "Detection of homozygous deletion of 13q14 in retinoblastomas" Invest. Ophthalmol. & Visual Sci. 27 (3) :194 (1986).
Bagchi et al., Cell 65:1063-1072 (1991).
Bookstein et al., Proc. Natl. Acad. Sci. USA 87:7762-7766 (1990).
Bookstein et al., Science 247:712-715 (1990).
Buchkovich et al., Cell 58:1097-1105 (1989).
Chen et al., Cell Growth & Differentiation 3:119-125 (1992).
Chen et al., Cell 58:1193-1198 (1989).
DeCaprio et al., Cell 58:1085-1095 (1989).
Fields et al., Science 249:1046-1049 (1990).
Fields et al., Nature 340:245-246 (1989).
Friend et al., Nature 323:643-646 (1986).
Goodrich et al., Cancer Research 52:1968-1973 (1992).
Hiebert et al., Proc. Natl. Acad. Sci. USA 86:3594-3598 (1989).
Horowitz et al., Science 243:937-940 (1989).
Hu et al., The EMBO Journal 9(4):1147-1155 (1990).
Huang et al., Science 242:1563-1566 (1988).
Huang et al., The EMBO Journal 9(6):1815-1822 (1990).
Keyomarsi et al., Cancer Research 51:3602-3609 (1991).
Lees et al., The EMBO Journal 10(13):4279-4290 (1991).
Lin et al., The EMBO Journal 10(4) :857-864 (1991).
Mudryj et al., Cell 65:1243-1253 (1991).
Mudryj et al., The EMBO Journal 9(7) :2179-2184 (1990).
Neill et al., Journal of Virology 65(10):5364-5373 (1991).
Shew et al., Proc. Natl. Acad. Sci. USA 87:6-10 (1990).
Shirodkar et al., Cell 68:157-166 (1992).
Sumegi et al., Cell Growth & Differentiation 247-250 (1990).
Takahashi et al., Proc. Natl. Acad. Sci. USA 88:5257-5261 (1991).
Wang et al., Cell Growth & Differentiation 233-239.
Wang et al., Cell Growth & Differentiation 1:429-437 (1990).
Whyte et al., Nature 334:124-129 (1988).
Lee et al., "The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity" Nature 329:642-645 (1987).
Lee Wen-Hwa
Shan Bei
Board of Regents of the University of Texas System
Loring Susan A.
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