Antibodies produced from lipopolysaccharide-stimulated monocyte/

Details Antibodies produced from lipopolysaccharide-stimulated monocyte/ Antibodies produced from lipopolysaccharide-stimulated monocyte/

1996-02-20

1997-10-14

Housel, James C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4381722, 43824027, 5303887, 53038873, 53038875, 5303884, C12P 2108, C12N 512, C07K 1618

Patent

active

056771509

ABSTRACT:
Lipopolysaccharide-stimulated monocyte/macrophage cell lines are used as antigens to obtain antibodies. Antibodies which inhibit intercellular adhesion of cells stimulated by a differentiation factor or which induce intercellular aggregation of cells in the process of differentiation under stimulation by a differentiation factor are disclosed. Such antibodies can be used to suppress immune responses and in clinical diagnosis of immune system disorders.

REFERENCES:
Harris et al., Tibtech, 11:42-44, 1993.
W. Waldmann et al., Immunology Today, 14(6):247-251, 1993.
I. Kawaki et al., Jpn. J. Bacteriol, 48(2):429-433, 1993.
Waldmann, T., Science, 252:1657-1662, 21 Jun. 1991.
Proceedings of Japanese Society for Immunology, vol. 22, Oct. 30, 1992, p. 258, along with translation (3 pages).
Davignon, Denise et al., J. Immunol, 127(2):590-595, 1981.

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