Antibodies of angiogenesis inhibiting domains CD148

Details Antibodies of angiogenesis inhibiting domains CD148 Antibodies of angiogenesis inhibiting domains CD148

2005-04-22

2008-11-11

Belyavskyi, Michail A (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C424S141100

Reexamination Certificate

active

07449555

ABSTRACT:
Anti-CD148 antibodies and antigen-binding regions thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding regions, are described. Also described are methods of using such antibodies and antigen-binding regions to bind CD148 epitopes and activate CD148 function, such as inhibition of angiogenesis. Epitopes that can be used to activate CD148 function and anti-angiogenesis activity are also described, as well as methods of identifying compounds that can bind them.

REFERENCES:
patent: 7176289 (2007-02-01), Daniel et al.
patent: 7205121 (2007-04-01), Palka-Hamblin et al.
patent: 2003/0215899 (2003-11-01), Meng et al.
patent: 2004/0161821 (2004-08-01), Palka-Hamblin et al.
patent: 2005/0272054 (2005-12-01), Cargill et al.
patent: 2005/0287140 (2005-12-01), Smothers et al.
patent: WO 2005/117970 (2005-12-01), None
International Search Report for International Application No. PCT/US2005/014084 (Feb. 26, 2007).

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