Antibodies immunoreactive with the T-cell growth factor, P40

Details Antibodies immunoreactive with the T-cell growth factor, P40 Antibodies immunoreactive with the T-cell growth factor, P40

1989-09-15

1992-10-20

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530351, 530808, 53038823, 5303892, 930141, 435 7021, 4351722, 424 858, 935 89, C07K 1528

Patent

active

051571129

ABSTRACT:
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present inventin relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.

REFERENCES:
patent: 4636463 (1987-01-01), Altman et al.
patent: 4935343 (1990-06-01), Allison et al.
Van Snick et al., Eur. J. Immunol 15, 1985, pp. 1148-1151.
Rolenk et al., J. Exp. Med, 169, 1989, pp. 1693-1701.
Ohara et al., Nature 315, 1985, pp. 333-336.

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