Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-11-12
2000-08-08
Huff, Sheela
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 5303891, 5303871, C07K 1600
Patent
active
061003840
ABSTRACT:
An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing several SH2 binding motifs, and a carboxy-terminal effector domain that can induce pseudohyphal budding in yeast. The invention also provides the novel signal mediator protein, and antibodies thereto. These biological molecules are useful as research tools and as diagnostic and therapeutic agents for the identification, detection and regulation of complex signaling events leading to morphological, potentially neoplastic, cellular changes.
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Kumar et al BBRC vol. 185 p. 1155, 1992.
CA 119:136335, 1993.
Sakai et al EMBO J. vol. 13 p. 3748, 1994.
Campbell, Monoclonal Antibody Technology, ed. Elsevier Pub. Chapter 1, 1984 .
Estojak Joanne
Golemis Erica A.
Law Susan F.
Fox Chase Cancer Center
Huff Sheela
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