Antibodies having binding specificity to ShET2, an enterotoxin o

Details Antibodies having binding specificity to ShET2, an enterotoxin o Antibodies having binding specificity to ShET2, an enterotoxin o

1995-06-06

1997-11-11

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303884, C07K 1600, C12P 2108

Patent

active

056865805

ABSTRACT:
Substantially pure enterotoxins of Shigella flexneri 2a are described, along with a method for obtaining the same, antibodies having binding specificity to the enterotoxins and a method for use of the enterotoxins to develop a non-reactogenic Shigella flexneri 2a vaccine candidate.

REFERENCES:
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patent: 5380648 (1995-01-01), Elango et al.
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Nataro et al, "Cloning and Sequencing of a New Plasmid-Encoded Enterotoxin in Enteroinvasive E. coli and Shigella", presented at the 29th U.S.-Japan Joint Conference on Cholera and Related Diarrheal Diseases, Dec. 2, 1992.
Noriega et al, "Construction and Characterization of Oral Attentuated Shigella Vaccine-Candidates and their Potential Use as Live Vector-Hyrbrid Vaccines", presented at the 29th U.S.-Japan Joint Conference on Cholera and Related Diarrheal Diseases, Dec. 2, 1992.
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