Antibodies for use in targeted and temporary treatment of...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S141100, C424S178100, C530S387100, C530S389100

Reexamination Certificate

active

09780205

ABSTRACT:
An antibody or an antibody fragment that binds to an epitope under specifically chosen conditions; the binding of which to the epitope is broken under specifically chosen different conditions. Also, an antibody or antibody fragment with which a diagnostically, therapeutically or cosmetically active substance is optionally conjugated, for targeted and temporary diagnostic, therapeutic, or cosmetic treatment of externally accessible parts of the human and animal body. Both the specifically chosen binding conditions and the conditions wherein the binding is broken lie within physiologically acceptable limits and involve pH and/or ionic strength. The antibody or antibody fragment can be used for targeted and temporary treatment of externally accessible parts of the human and animal body. Also, a composition including at least one antibody, or a fragment thereof, according to the invention such as a teeth cleaning agent, mouthwash, mouth spray, chewing tablet, cream or ointment.

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patent: 5571511 (1996-11-01), Fischer
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patent: 0 736 544 (1996-10-01), None
patent: WO 87/03205 (1987-06-01), None
patent: WO 00/09164 (2000-02-01), None
Goding ed., Monoclonal Antibodies: Principles and Practice, 1983, pp. 44-45 Academic Press, New York.
Cole et al., Immunol. &Infect. Diseases 1993, 3, 33-35.
Weir ed. Immunochemistry, vol. 1, 1986, p. 38 1-38 15 Blackwell Scientific Publication, Oxford.
PCT International Preliminary Examination Report, PCT/NL99/00509, dated Nov. 15, 2000, 7 pages.
PCT International Search Report, PCT/NL99/00509, dated Nov. 29, 1999, 4 pages.
Abstract, XP-002094889, Oosterwaal et al., “Clearance of a topically applied fluorescein gel from periodontal pockets”,J. Clin. Periodontal, 17(9) 1 page, Oct. 1990.
PCT International Preliminary Examination Report with amended claims, PCT/NL99/00509, dated Nov. 15, 2000, 12 pages.

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