Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1997-10-14
2000-12-26
Navarro, Albert
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435329, 435331, 5303882, 53038885, C12N 506, C12N 516, C07K 1600, C12P 2108
Patent
active
061657840
ABSTRACT:
Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals, and postmortem detection methods, are described. In one aspect, the invention is directed to a non-invasive diagnostic assay using third eyelid-associated lymphoid tissue. In another aspect, the invention is directed to monoclonal antibodies that specifically bind a conserved epitope of PrP-Sc protein in fixed or frozen treated tissue.
REFERENCES:
patent: 4806627 (1989-02-01), Wisniewski et al.
Sevier et al (Clinical Chemistry vol. 27 No. 11 pp. 1797-1806), 1981.
K.I. O'Rourke et al., "PrP Genotypes and Experimental Scrapie in Orally inoculated Suffolk Sheep in the United States," Journal of General Virology 78:975-978 (1997).
K.I. O'Rourke, T.P. Huff, C.W. Leathers, M.M. Robinson and J.R. Gorham, "SCID0 Mouse Spleen Does Not Support Scrapie Agent Replication," Journal of General Virology 75:1511-1514 (1994).
K.I. O'Rourke, R.P. Melco and J.R. Mickelson, "Allelic Frequencies of an Ovine Scrapie Susceptibility Gene," Animal Biotechnology 75(2):155-162 (1996).
S.C. Arya, "Diagnosis of New Variant Creutzfeldt-Jakob Disease by Tonsil Biopsy," The Lancet 349:1322-1323 (May 1997).
P.E. Bendheim et al., "Nearly Ubiquitous Tissue Distribution of The Scrapie Agent Precursor Protein," Neurology 42:149-156 (1992).
W.J. Hadlow, C.M. Eklund, R.C. Kennedy, T.A. Jackson, H.W. Whitford, & C.C. Boyle, "Course of Experimental Scrapie Virus Infection in the Goat," Journal of Infectious Diseases 129(5):559-567(1974).
W.J. Hadlow, R.C. Kennedy & R.E Race, "Natural Infection of Suffolk Sheep with Scrapie Virus," Journal of Infectious Diseases 146(5):657-664 (1982).
M. Haritani, Y.I. Spencer & G.A.H. Wells, "Hydrated Autoclave Pretreatment Enhancement of Prion Protein Immunoreactivity in Formalin-fixed Bovine Spongiform Encephalopathy-Affected Brain," Acta Neuropathol 87:86-90 (1994).
A.F. Hill, M. Zeidler, J. Ironside & J. Collinge, "Diagnosis of New Variant Creutzfeldt-Jakob Disease by Tonsil Biopsy," The Lancet 349:99-100 (Jan. 1997).
M. Horiuchi, N. Yamazaki, T. Ikeda, N. Ishiguro & M. Shinagawa, "A Cellular Form of Prion Protein (PrP.sup.c) Exists in Many Non-neuronal Tissues of Sheep," Journal of General Virology 76:2583-2587 (1995).
Y. Ikegami, M. Ito, H. Isomura, E. Momotani, K. Sasaki, Y. Muramatsu, N. Ishiguro & M. Shinagawa, "Pre-clinical and Clinical Diagnosis of Scrapie by Detection of PrP Protein in Tissues of Sheep," The Veterinary Record 128:271-275 (1991).
R.J. Kascsak, R. Fersko, D. Pulgiano, R. Rubinstein & R.I. Carp, "Immunodiagnosis of Prion Disease," Immunological Investigations 26(1&2):259-268 (1997).
T. Kawashima, H. Furukawa D. Doh-ura & T. Iwaki, "Diagnosis of New Variant Creutzfeldt-Jakob Disease by Tonsil Biopsy," The Lancet 50:68-69 (1997).
P.A. McBride, P. Eikelenboom, G. Kraal, H. Fraser & M.E. Bruce, "PrP Protein is Associated with Follicular Dendritic Cells of Spleens and Lymph Nodes in Uninfected and Scrapie-Infected Mice," Journal of Pathology 168:413-418 (1992).
J.M. Miller, A.L. Jenny, W.D. Taylor, R.F. Marsh, R. Rubenstein & R.E. Race "Immunohistochemical Detection of Prion Protein in Sheep with Scrapie," J Vet Diagn Invest 5:309-316 (1993).
J.M. Miller et al., "Detection of Prion Protein in Formalin-Fixed Brain by Hydrated Autoclaving Imnmunohistochemistry for the Diagnosis of Scrapie in Sheep," J Vet Diagn Invest 6:366-368 (1994).
Y. Muramatsu, A. Onodera, M. Horiuchi, N. Ishiguro & M. Shinagawa, "Detection of PrP.sup.Sc in Sheep at the Preclinical Stage of Scrapie and its Significance for Diagnosis of Insidious Infection," Archives of Virology 134:427-432 (1993).
Y. Muramatsu, A. Onodera, M. Horiuchi, N. Ishiguro & M. Shinagawa, "The Significance of PrP.sup.Sc Detection for the Diagnosis of Insidious Scrapie," Annals of the New York Academy of Sciences 724:347-349 (1994).
I.H. Pattison & G.C. Millson, "Distribution of the Scrapie Agent in the Tissues of Experimentally Inoculated Goats," J Comp Path 72:233-244 (1962).
R. Race, D. Ernst, A. Jenny, W. Taylor, D. Sutton & B. Caughey, "Diagnostic Implications of Detection of Proteinase K-Resistant Protein in Spleen, Lymph Nodes, and Brain of Sheep," Am J Vet Res 53,6:883-889 (1992).
B.E.C. Schreuder. L.J.M. van Keulen, M.E.W. Vromans, J.P.M. Langeveld & M.A. Smits "Preclinical Test for Prion Diseases," Nature 381:563 (1996).
L.J.M. van Keulen, B.E.C. Schreuder, R.H. Meloen, G. Mooij-Harkes, M.E.W. Vromans & J.P.M. Langeveld, "Immunohistochemical Detection of Prion Protein in Lymphoid Tissues of Sheep with Natural Scrapie,"; Journal of Clinical Microbiology 35(5):1228-1231 (1996).
L.J.M. van Keulen, B.E.C. Schreuder, R.H. Meloen, M. Poelen-Van Den Berg, G. Mooij-Harkes, M.E.W. Vromans & J.P.M. Langeveld, "Immunohistochemical Detection and Localization of Prion Protein in Brain Tissue of Sheep with Natural Scrapie," Vet Pathol 32:299-308 (1995).
Baszler Timothy V.
Knowles Donald P.
O'Rourke Katherine I.
Parish Steven M.
Connor Margaret A.
Fado John D.
Navarro Albert
Silverstein M. Howard
The United States of America as represented by the Secretary of
LandOfFree
Antibodies for the detection of prion protein as an indication o does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies for the detection of prion protein as an indication o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies for the detection of prion protein as an indication o will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-993579