Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-01-04
2011-01-04
Lucas, Zachariah (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007920, C435S040500, C435S040520, C530S388150, C530S389300
Reexamination Certificate
active
07863006
ABSTRACT:
This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an epitope characteristic of a human prion protein which is not found in the prion proteins of other species. In some embodiments, the antibodies are not cross-reactive with cow, Syrian Gold hamster, mouse, or rat prions. The application also includes a conformation-dependent immunoassay method for detecting pathogenic prions in a sample containing a prion (PrP) protein. The PrP protein may be present in a first conformation and a second conformation, such as PrPcand PrPScin which the two conformations have different binding affinity for the antibody used to detect them.
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Bellon Anne
Groener Albrecht
Lang Wiegang
Vey Martin
CSL Behring GmbH
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Horning Michelle
Lucas Zachariah
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